Molecular structure of NE 100 hydrochloride, CAS Number: 149409-57-4
NE 100 hydrochloride (CAS 149409-57-4)
See product citations (21)
Alternate Names:
4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanamine hydrochloride
Application:
NE 100 hydrochloride is a potent and selective σ1 receptor antagonist
CAS Number:
149409-57-4
Purity:
>98%
Molecular Weight:
391.98
Molecular Formula:
C23H33NO2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NE 100 hydrochloride is a potent and selective Sigma Receptor (sigma1 receptor) antagonist (Ki = 0.86 nM) that displays > 55-fold selectivity over sigma2 receptors and > 6000-fold selectivity over D1, D2, 5-HT1A, 5-HT2 and PCP receptors. NE 100 hydrochloride displays antipsychotic activity in vivo and additionallt Exhibits reversible binding (Kd = 1.2 nM).
NE 100 hydrochloride (CAS 149409-57-4) References
- Prediction of oral clearance from in vitro metabolic data using recombinant CYPs: comparison among well-stirred, parallel-tube, distributed and dispersion models. | Yamamoto, T., et al. 2005. Xenobiotica. 35: 627-46. PMID: 16192112
- Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of fluvoxamine: role of sigma-1 receptors. | Hashimoto, K., et al. 2007. Neuropsychopharmacology. 32: 514-21. PMID: 16495935
- Sigma receptor 1 modulates endoplasmic reticulum stress in retinal neurons. | Ha, Y., et al. 2011. Invest Ophthalmol Vis Sci. 52: 527-40. PMID: 20811050
- Mechanisms of activation of nucleus accumbens neurons by cocaine via sigma-1 receptor-inositol 1,4,5-trisphosphate-transient receptor potential canonical channel pathways. | Barr, JL., et al. 2015. Cell Calcium. 58: 196-207. PMID: 26077147
- Cocaine inhibits store-operated Ca2+ entry in brain microvascular endothelial cells: critical role for sigma-1 receptors. | Brailoiu, GC., et al. 2016. Biochem J. 473: 1-5. PMID: 26467159
- Effects of fluvoxamine on nerve growth factor-induced neurite outgrowth inhibition by dexamethasone in PC12 cells. | Matsushima, Y., et al. 2019. Biosci Biotechnol Biochem. 83: 659-665. PMID: 30543144
- Cholinesterase inhibitor rivastigmine enhances nerve growth factor-induced neurite outgrowth in PC12 cells via sigma-1 and sigma-2 receptors. | Terada, K., et al. 2018. PLoS One. 13: e0209250. PMID: 30557385
- Sertraline inhibits nerve growth factor-induced neurite outgrowth in PC12 cells via a mechanism involving the sigma-1 receptor. | Matsushima, Y., et al. 2019. Eur J Pharmacol. 853: 129-135. PMID: 30902656
- Inhibition of SARS-CoV-2 infection in human iPSC-derived cardiomyocytes by targeting the Sigma-1 receptor disrupts cytoarchitecture and beating. | Salerno, JA., et al. 2021. PeerJ. 9: e12595. PMID: 35036128
- Pharmacological Analysis of GABAA Receptor and Sigma1R Chaperone Interaction: Research Report I-Investigation of the Anxiolytic, Anticonvulsant and Hypnotic Effects of Allosteric GABAA Receptors' Ligands. | Voronin, MV., et al. 2023. Int J Mol Sci. 24: PMID: 37298532
- Characteristics of binding of [3H]NE-100, a novel sigma-receptor ligand, to guinea-pig brain membranes. | Tanaka, M., et al. 1995. Naunyn Schmiedebergs Arch Pharmacol. 351: 244-51. PMID: 7609777
- NE-100, a novel sigma receptor ligand: in vivo tests. | Okuyama, S., et al. 1993. Life Sci. 53: PL285-90. PMID: 7901723
- NE-100, a novel potent sigma ligand, preferentially binds to sigma 1 binding sites in guinea pig brain. | Chaki, S., et al. 1994. Eur J Pharmacol. 251: R1-2. PMID: 8137864
Inhibitor of:
Sigma Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NE 100 hydrochloride, 10 mg | sc-204121 | 10 mg | $162.00 | |||
NE 100 hydrochloride, 50 mg | sc-204121A | 50 mg | $683.00 | |||
NE 100 hydrochloride, 500 mg | sc-204121B | 500 mg | $4080.00 | |||
NE 100 hydrochloride, 1 g | sc-204121C | 1 g | $7140.00 | |||
NE 100 hydrochloride, 10 g | sc-204121D | 10 g | $64566.00 |