NDUFV1 Antibody (14.8): sc-100566

NDUFV1 Antibody (14.8) is a mouse monoclonal IgG2b kappa light chain antibody that detects NDUFV1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-NDUFV1 antibody (14.8) is available as a non-conjugated monoclonal isotype antibody. NDUFV1 protein, also known as NADH dehydrogenase ubiquinone flavoprotein 1, plays a crucial role in the electron transport chain as a core subunit of Complex I, which is essential for cellular respiration. NDUFV1 is located in the mitochondrial inner membrane, where NDUFV1 facilitates the transfer of electrons from NADH to ubiquinone, a process vital for ATP synthesis. Proper functioning of NDUFV1 is critical, as defects in NDUFV1 gene can lead to complex I deficiency, resulting in severe neurological disorders such as Leigh syndrome. NDUFV1 structure includes a highly conserved NADH-binding site, which is essential for enzymatic activity, and NDUFV1 localization to the matrix side of the inner membrane underscores its importance in maintaining mitochondrial function and energy production.

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NDUFV1 Antibody (14.8) References:

1. Mutant NDUFV1 subunit of mitochondrial complex I causes leukodystrophy and myoclonic epilepsy.  |  Schuelke, M., et al. 1999. Nat Genet. 21: 260-1. PMID: 10080174
2. Large-scale deletion and point mutations of the nuclear NDUFV1 and NDUFS1 genes in mitochondrial complex I deficiency.  |  Bénit, P., et al. 2001. Am J Hum Genet. 68: 1344-52. PMID: 11349233
3. Mitochondrial complex I mutations in Caenorhabditis elegans produce cytochrome c oxidase deficiency, oxidative stress and vitamin-responsive lactic acidosis.  |  Grad, LI. and Lemire, BD. 2004. Hum Mol Genet. 13: 303-14. PMID: 14662656
4. The human mitochondrial NADH: ubiquinone oxidoreductase 51-kDa subunit maps adjacent to the glutathione S-transferase P1-1 gene on chromosome 11q13.  |  Spencer, SR., et al. 1992. Genomics. 14: 1116-8. PMID: 1478657
5. Chromosomal localization of the human gene encoding the 51-kDa subunit of mitochondrial complex I (NDUFV1) to 11q13.  |  Ali, ST., et al. 1993. Genomics. 18: 435-9. PMID: 8288251
6. Cloning of the human mitochondrial 51 kDa subunit (NDUFV1) reveals a 100% antisense homology of its 3'UTR with the 5'UTR of the gamma-interferon inducible protein (IP-30) precursor: is this a link between mitochondrial myopathy and inflammation?  |  Schuelke, M., et al. 1998. Biochem Biophys Res Commun. 245: 599-606. PMID: 9571201
7. The structure of the human NDUFV1 gene encoding the 51-kDa subunit of mitochondrial complex I.  |  de Coo, RF., et al. 1999. Mamm Genome. 10: 49-53. PMID: 9892733

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NDUFV1 Antibody (14.8) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-NDUFV1 Antibody (14.8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NDUFV1 Antibody (14.8) Specifications

Alternate Product Name: NDUFV1

Product Clone Name: 14.8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 365-465

Epitope Target: NDUFV1

Epitope Species: human

Product Reactivity/Detection: NDUFV1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for NDUFV1 Antibody (14.8): N/A