NDUFB3 Antibody (F-11): sc-398196

NDUFB3 Antibody (F-11) is a mouse monoclonal IgG2a antibody that detects NDUFB3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NDUFB3, also known as NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 3, is a crucial 98 amino acid hydrophobic protein that plays a significant role as an accessory subunit of Complex I in the mitochondrial inner membrane. NDUFB3 is essential for the proper functioning of the electron transport chain, facilitating the transfer of electrons from NADH to ubiquinone, ultimately contributing to ATP synthesis by creating an electrochemical proton gradient. NDUFB3 localization to the matrix side of the inner mitochondrial membrane ensures effective participation in enzymatic reactions that drive cellular energy production. The intricate structure of Complex I, which includes at least 45 different subunits, highlights NDUFB3′s importance in maintaining the stability and functionality of this multi-protein complex, making anti-NDUFB3 antibody (F-11) an invaluable tool for researchers studying mitochondrial function and energy metabolism.

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NDUFB3 Antibody (F-11) References:

1. Assignment of human NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 (NDUFB3) and of its four pseudogenes to human chromosomes 2q31.3, 1p13.3-->p13.1, 9q32-->q34.1, 14q22.3-->q23.1 and 14q32.2 by radiation hybrid mapping.  |  Jensen, LL., et al. 2001. Cytogenet Cell Genet. 93: 147-50. PMID: 11474204
2. A recurrent mitochondrial p.Trp22Arg NDUFB3 variant causes a distinctive facial appearance, short stature and a mild biochemical and clinical phenotype.  |  Alston, CL., et al. 2016. J Med Genet. 53: 634-41. PMID: 27091925
3. The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes.  |  Davydova, E., et al. 2021. Nat Commun. 12: 891. PMID: 33563959
4. Proteomic analysis of decidua in patients with recurrent pregnancy loss (RPL) reveals mitochondrial oxidative stress dysfunction.  |  Yin, XJ., et al. 2021. Clin Proteomics. 18: 9. PMID: 33618676
5. Clinical Relevance and Tumor Growth Suppression of Mitochondrial ROS Regulators along NADH:Ubiquinone Oxidoreductase Subunit B3 in Thyroid Cancer.  |  Zhu, J., et al. 2022. Oxid Med Cell Longev. 2022: 8038857. PMID: 35087620
6. Hepatocellular carcinoma cells downregulate NADH:Ubiquinone Oxidoreductase Subunit B3 to maintain reactive oxygen species homeostasis.  |  Zhang, Z., et al. 2024. Hepatol Commun. 8: PMID: 38437062
7. The role of lactylation in plasma cells and its impact on rheumatoid arthritis pathogenesis: insights from single-cell RNA sequencing and machine learning.  |  Fu, W., et al. 2024. Front Immunol. 15: 1453587. PMID: 39421742
8. Comprehensive Analysis of NADH:Ubiquinone Oxidoreductase Subunit B3 in Gynecological Tumors and Identification of Its Natural Inhibitor Wedelolactone.  |  Li, H., et al. 2024. Chem Biol Drug Des. 104: e70006. PMID: 39469770
9. Role of COX6C and NDUFB3 in septic shock and stroke.  |  Tian, W., et al. 2024. Open Med (Wars). 19: 20241050. PMID: 39655053
10. New Posttranslational Modification Lactylation Brings New Inspiration for the Treatment of Rheumatoid Arthritis.  |  Yang, Y., et al. 2024. J Inflamm Res. 17: 11845-11860. PMID: 39758940

The preferred NDUFB3 antibody is NDUFB3 Antibody (F-12): sc-393351.