Molecular structure of NDSB-201, CAS Number: 15471-17-7
NDSB-201 (CAS 15471-17-7)
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Alternate Names:
3-(1-Pyridinio)-1-propanesulfonate; PPS
Application:
NDSB-201 is a member of the class of nondetergent sulfobetaines
CAS Number:
15471-17-7
Purity:
≥99%
Molecular Weight:
201.2
Molecular Formula:
C8H11NO3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NDSB-201 is a member of the class of nondetergent sulfobetaines. Unlike CHAPS and other zwittergents, NDSBs are nondenaturing even at 1 M concentrations. NDSBs have been used to improve the efficiency of solubilization of membrane proteins, to isolate nuclear proteins, to chromatographically purify halophilic proteins in low ionic strength buffers, and to crystallize proteins. They are zwitterionic over a wide pH range and do not absorb significantly in the near UV range. They are reported to prevent protein aggregation and facilitate the renaturation of chemically and thermally denatured proteins. NDSBs can be easily removed by dialysis.
NDSB-201 (CAS 15471-17-7) References
- Preparation of functional recombinant protein from E. coli using a nondetergent sulfobetaine. | Chong, Y. and Chen, H. 2000. Biotechniques. 29: 1166-7. PMID: 11126113
- Crystallization and preliminary X-ray diffraction analysis of lectin-1 from Pseudomonas aeruginosa. | Karaveg, K., et al. 2003. Acta Crystallogr D Biol Crystallogr. 59: 1241-2. PMID: 12832772
- High yield expression, refolding, and characterization of recombinant interferon alpha2/alpha8 hybrids in Escherichia coli. | Platis, D. and Foster, GR. 2003. Protein Expr Purif. 31: 222-30. PMID: 14550640
- Mapping the RNA-binding domain on the Apple chlorotic leaf spot virus movement protein. | Isogai, M. and Yoshikawa, N. 2005. J Gen Virol. 86: 225-229. PMID: 15604450
- Production of nonclassical inclusion bodies from which correctly folded protein can be extracted. | Jevsevar, S., et al. 2005. Biotechnol Prog. 21: 632-9. PMID: 15801811
- Family 47 alpha-mannosidases in N-glycan processing. | Mast, SW. and Moremen, KW. 2006. Methods Enzymol. 415: 31-46. PMID: 17116466
- 3-(1-Pyridinio)propanesulfonate and 3-(benzyldimethylammonio)propanesulfonate monohydrate. | Koclega, KD., et al. 2007. Acta Crystallogr C. 63: o114-6. PMID: 17284802
- Crystal structure of chondroitin polymerase from Escherichia coli K4. | Osawa, T., et al. 2009. Biochem Biophys Res Commun. 378: 10-4. PMID: 18771653
- Purification, crystallization and preliminary crystallographic studies of SPCI-chymotrypsin complex at 2.8 A resolution. | da Silva, AJ., et al. 2008. Acta Crystallogr Sect F Struct Biol Cryst Commun. 64: 914-7. PMID: 18931434
- A novel replicative enzyme encoded by the linear Arthrobacter plasmid pAL1. | Kolkenbrock, S., et al. 2010. J Bacteriol. 192: 4935-43. PMID: 20675469
- KRAS-induced actin-interacting protein is required for the proper localization of inositol 1,4,5-trisphosphate receptor in the epithelial cells. | Fujimoto, T., et al. 2011. Biochem Biophys Res Commun. 407: 438-43. PMID: 21420385
- Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae. | Leyrat, C., et al. 2014. Elife. 3: e02674. PMID: 24842877
- The non-detergent sulfobetaine-201 acts as a pharmacological chaperone to promote folding and crystallization of the type II TGF-β receptor extracellular domain. | Wangkanont, K., et al. 2015. Protein Expr Purif. 115: 19-25. PMID: 26073093
- Non-detergent sulphobetaines: a new class of mild solubilization agents for protein purification. | Vuillard, L., et al. 1995. Biochem J. 305 (Pt 1): 337-43. PMID: 7826351
- Non-detergent sulphobetaines: a new class of molecules that facilitate in vitro protein renaturation. | Goldberg, ME., et al. 1996. Fold Des. 1: 21-7. PMID: 9079360
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NDSB-201, 25 g | sc-202237 | 25 g | $40.00 | |||
NDSB-201, 250 g | sc-202237A | 250 g | $114.00 |