Molecular structure of NDSB-195, CAS Number: 160255-06-1
NDSB-195 (CAS 160255-06-1)
Alternate Names:
Dimethylethylammonium Propane Sulfonate; 3-[ethyl(dimethyl)azaniumyl]propane-1-sulfonate
Application:
NDSB-195 is a nondetergent sulfobetaine used to solubilize proteins
CAS Number:
160255-06-1
Purity:
≥95%
Molecular Weight:
195.28
Molecular Formula:
C7H17NO3S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
NDSB-195 is a member of the class of nondetergent sulfobetaines. Unlike CHAPS and other zwittergents, NDSBs are nondenaturing even at 1 M concentrations. NDSBs have been used to improve the efficiency of solubilization of membrane proteins, to chromatographically purify halophilic proteins in low ionic strength buffers, to isolate nuclear proteins, and to crystallize proteins. They are zwitterionic over a wide pH range and do not absorb significantly in the near UV range. Reported to facilitate the renaturation of chemically and thermally denatured proteins and prevent protein aggregation. NDSB-195 can be easily removed by dialysis. It enhances the solubility of other substances and reduces the surface tension of solutions. Furthermore, NDSB-195 is highly adept at binding to molecules.
NDSB-195 (CAS 160255-06-1) References
- Preparation, crystallization and preliminary X-ray diffraction analysis of the DNA-binding domain of the Ets transcription factor in complex with target DNA. | Suwa, Y., et al. 2008. Acta Crystallogr Sect F Struct Biol Cryst Commun. 64: 171-4. PMID: 18323600
- Interaction of anti-aggregation agent dimethylethylammonium propane sulfonate with acidic fibroblast growth factor. | Xiang, L., et al. 2008. J Magn Reson. 194: 147-51. PMID: 18617428
- The non-detergent sulfobetaine-201 acts as a pharmacological chaperone to promote folding and crystallization of the type II TGF-β receptor extracellular domain. | Wangkanont, K., et al. 2015. Protein Expr Purif. 115: 19-25. PMID: 26073093
- Protein stabilizer, NDSB-195, enhances the dynamics of the β4 -α2 loop of ubiquitin. | Wang, H., et al. 2016. J Pept Sci. 22: 174-80. PMID: 26856691
- NMR spectra of PB2 627, the RNA-binding domain in influenza A virus RNA polymerase that contains the pathogenicity factor lysine 627, and improvement of the spectra by small osmolytes. | Kato, YS., et al. 2017. Biochem Biophys Rep. 12: 129-134. PMID: 29090273
- Structural basis of cytokine-mediated activation of ALK family receptors. | De Munck, S., et al. 2021. Nature. 600: 143-147. PMID: 34646012
- Isolation and Crystallization of the D156C Form of Optogenetic ChR2. | Zhang, L., et al. 2022. Cells. 11: PMID: 35269517
- The FUSION protein crystallization screen. | Gorrec, F. and Bellini, D. 2022. J Appl Crystallogr. 55: 310-319. PMID: 35497656
- Effects of Chemical Additives in Refolding Buffer on Recombinant Human BMP-2 Dimerization and the Bioactivity on SaOS-2 Osteoblasts. | Manissorn, J., et al. 2023. ACS Omega. 8: 2065-2076. PMID: 36687022
- Ent2 Governs Morphogenesis and Virulence in Part through Regulation of the Cdc42 Signaling Cascade in the Fungal Pathogen Candida albicans. | Lash, E., et al. 2023. mBio. 14: e0343422. PMID: 36809010
- Non-detergent sulphobetaines: a new class of mild solubilization agents for protein purification. | Vuillard, L., et al. 1995. Biochem J. 305 (Pt 1): 337-43. PMID: 7826351
- A new additive for protein crystallization. | Vuillard, L., et al. 1994. FEBS Lett. 353: 294-6. PMID: 7957878
- Non-detergent sulphobetaines: a new class of molecules that facilitate in vitro protein renaturation. | Goldberg, ME., et al. 1996. Fold Des. 1: 21-7. PMID: 9079360
- Functional properties of the separate subunits of human DNA helicase II/Ku autoantigen. | Ochem, AE., et al. 1997. J Biol Chem. 272: 29919-26. PMID: 9368068
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NDSB-195, 5 g | sc-205912 | 5 g | $180.00 | |||
NDSB-195, 25 g | sc-205912A | 25 g | $460.00 |