(−)-AS 115 (CAS 926657-43-4)
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KIAA1363 is a 2-acetyl monoacylglyceryl ether (MAGE) hydrolase which is upregulated in aggressive cancers from an array of tissues.1 The enzyme catalyzes the hydrolysis of the 2-acetyl MAGE to MAGE and serves as a central enzyme in the PAF and LPA signaling network.2 AS 115 is a potent and selective inactivator of KIAA1363, displaying an IC50 value of 150 nM when tested as a racemic mixture in the invasive ovarian cancer cell line SK0V-3.2 Treatment of SKOV-3 cells with 10 µM AS-115 for 4 hours significantly reduced the formation of MAGE, alkyl-lysophosphatidylcholine, and alkyl-lysophosphatidic acid. The activity of the individual enantiomers of AS 115, i.e. (+)-AS 115 and (−)-AS 115, has not been determined.
(−)-AS 115 (CAS 926657-43-4) References
- Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness. | Jessani, N., et al. 2002. Proc Natl Acad Sci U S A. 99: 10335-40. PMID: 12149457
- An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling. | Chiang, KP., et al. 2006. Chem Biol. 13: 1041-50. PMID: 17052608
- Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages. | Sakai, K., et al. 2014. J Lipid Res. 55: 2033-40. PMID: 24868095
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(−)-AS 115, 100 µg | sc-221270 | 100 µg | $94.00 | |||
(−)-AS 115, 500 µg | sc-221270A | 500 µg | $424.00 |