NCAM2 Antibody (44): sc-136328

NCAM2 Antibody (44) is a mouse monoclonal IgG1 kappa light chain antibody that detects NCAM2 protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-NCAM2 antibody (44) is available in both non-conjugated and various conjugated forms, including agarose and horseradish peroxidase (HRP). NCAM2, also known as neural cell adhesion molecule 2, is an 837 amino acid glycoprotein encoded by the human gene NCAM2, which plays a crucial role in cell adhesion and signaling during neural development. NCAM2 features five immunoglobulin-like domains and two fibronectin type III domains, which are essential for structural integrity and function in mediating cell-cell interactions. NCAM2 expression is particularly prominent in the adult and fetal brain, highlighting NCAM2′s importance in neurodevelopmental processes. NCAM2 is implicated in various neurological conditions, including certain phenotypes associated with Down syndrome, as NCAM2 overexpression can significantly enhance the adhesion properties of neural cells. Additionally, regulation of NCAM2 by Stat5, which binds to NCAM2 intron in response to cytokine signaling, underscores NCAM2′s involvement in immune responses and potential impact on neural cell behavior.

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NCAM2 Antibody (44) References:

1. Immunotargeting of human small cell lung cancer xenografts in athymic mice using a monoclonal antibody (RNL-1) against a neuroendocrine-related antigen.  |  Mijnheere, EP., et al. 1991. Br J Cancer Suppl. 14: 78-81. PMID: 1645579
2. Biodistribution of a monoclonal antibody (RNL-1) against the neural cell adhesion molecule (NCAM) in athymic mice bearing human small-cell lung-cancer xenografts.  |  Boerman, OC., et al. 1991. Int J Cancer. 48: 457-62. PMID: 1645701
3. Plasma cells in multiple myeloma express a natural killer cell-associated antigen: CD56 (NKH-1; Leu-19).  |  Van Camp, B., et al. 1990. Blood. 76: 377-82. PMID: 1695113
4. Novel antigens characteristic of neuroendocrine malignancies.  |  Broers, JL., et al. 1991. Cancer. 67: 619-33. PMID: 1845952
5. Differential spectrum of expression of neural cell adhesion molecule isoforms and L1 adhesion molecules on human neuroectodermal tumors.  |  Figarella-Branger, DF., et al. 1990. Cancer Res. 50: 6364-70. PMID: 2400996
6. Identity of Leu-19 (CD56) leukocyte differentiation antigen and neural cell adhesion molecule.  |  Lanier, LL., et al. 1989. J Exp Med. 169: 2233-8. PMID: 2471777
7. Clinical characterization of non-small-cell lung cancer tumors showing neuroendocrine differentiation features.  |  Berendsen, HH., et al. 1989. J Clin Oncol. 7: 1614-20. PMID: 2553880
8. Detection of small cell lung cancer metastases in bone marrow aspirates using monoclonal antibody directed against neuroendocrine differentiation antigen.  |  Berendsen, HH., et al. 1988. J Clin Pathol. 41: 273-6. PMID: 2834417
9. Simultaneous standard light microscopy and immunohistology on bronchoscopically procured lung cancer specimens.  |  Berendsen, HH., et al. 1988. Eur J Cancer Clin Oncol. 24: 915-21. PMID: 2844544
10. Characterization of three new variant type cell lines derived from small cell carcinoma of the lung.  |  de Leij, L., et al. 1985. Cancer Res. 45: 6024-33. PMID: 2998591

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NCAM2 Antibody (44) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-NCAM2 Antibody (44) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NCAM2 Antibody (44) Specifications

Alternate Product Name: NCAM2

Product Clone Name: 44

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 479-677

Epitope Target: NCAM2

Epitope Species: mouse

Product Reactivity/Detection: NCAM2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for NCAM2 Antibody (44): AC: Agarose, HRP: Horseradish Peroxidase