Molecular structure of NBI-31772, CAS Number: 374620-70-9
NBI-31772 (CAS 374620-70-9)
Alternate Names:
[1-(3′,4′-Dihydroxybenzoyl)-6,7-dihydroxyisoquinoline-3-carboxylic Acid]
Application:
NBI-31772 is an insulin-like growth factor-I binding protein (IGFBP) ligand
CAS Number:
374620-70-9
Purity:
≥95%
Molecular Weight:
341.27
Molecular Formula:
C17H11NO7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NBI-31772 is a non-peptide ligand. Exhibits high-affinity towards all six human insulin-like growth factor-I binding proteins (IGFBPs). NBI-31772 displaces insulin-like growth factor-I (IGF-I) from the IGF-I:IGFBP complex in 3T3 fibroblasts, but does not interact with the IGF receptors.
NBI-31772 (CAS 374620-70-9) References
- Neuroprotective effects of insulin-like growth factor-binding protein ligand inhibitors in vitro and in vivo. | Mackay, KB., et al. 2003. J Cereb Blood Flow Metab. 23: 1160-7. PMID: 14526226
- Pharmacological disruption of insulin-like growth factor 1 binding to IGF-binding proteins restores anabolic responses in human osteoarthritic chondrocytes. | De Ceuninck, F., et al. 2004. Arthritis Res Ther. 6: R393-403. PMID: 15380039
- The effects of the insulin-like growth factor-I aptamer, NBI-31772, on glucose homeostasis in the mouse. | Silha, JV. and Murphy, LJ. 2005. Can J Physiol Pharmacol. 83: 557-63. PMID: 16091781
- Increasing the levels of insulin-like growth factor-I by an IGF binding protein inhibitor produces anxiolytic and antidepressant-like effects. | Malberg, JE., et al. 2007. Neuropsychopharmacology. 32: 2360-8. PMID: 17342171
- Development of a scintillation proximity assay for human insulin-like growth factor-binding protein 4 compatible with inhibitor high-throughput screening. | Khawaja, XZ. 2007. Anal Biochem. 366: 80-6. PMID: 17482135
- Modulation of insulin-like growth factor (IGF)-I and IGF-binding protein interactions enhances skeletal muscle regeneration and ameliorates the dystrophic pathology in mdx mice. | Schertzer, JD., et al. 2007. Am J Pathol. 171: 1180-8. PMID: 17823291
- IGF-I gene delivery promotes corticospinal neuronal survival but not regeneration after adult CNS injury. | Hollis, ER., et al. 2009. Exp Neurol. 215: 53-9. PMID: 18938163
- In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration. | Choi, WY., et al. 2013. Development. 140: 660-6. PMID: 23293297
- Igf Binding Proteins Protect Undifferentiated Spermatogonia in the Zebrafish Testis Against Excessive Differentiation. | Safian, D., et al. 2016. Endocrinology. 157: 4423-4433. PMID: 27689414
- Insulin-like growth factor I and its binding protein-3 are regulators of lactation and maternal responsiveness. | Lékó, AH., et al. 2017. Sci Rep. 7: 3396. PMID: 28611445
- Follicle-Stimulating Hormone Regulates igfbp Gene Expression Directly or via Downstream Effectors to Modulate Igf3 Effects on Zebrafish Spermatogenesis. | Safian, D., et al. 2017. Front Endocrinol (Lausanne). 8: 328. PMID: 29209278
- Insulin-like growth factor binding proteins inhibit oocyte maturation of zebrafish. | Li, J., et al. 2019. Gen Comp Endocrinol. 281: 83-90. PMID: 31170402
- Insulin-like growth factor binding protein 4 loaded electrospun membrane ameliorating tendon injury by promoting retention of IGF-1. | Wang, H., et al. 2023. J Control Release. 356: 162-174. PMID: 36868516
Inhibitor of:
IGFBP, and IGFBP5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NBI-31772, 1 mg | sc-222047A | 1 mg | $39.00 | |||
NBI-31772, 5 mg | sc-222047 | 5 mg | $162.00 | |||
NBI-31772, 10 mg | sc-222047B | 10 mg | $267.00 | |||
NBI-31772, 25 mg | sc-222047C | 25 mg | $573.00 |