Molecular structure of NBI 27914 hydrochloride, CAS Number: 184241-44-9
NBI 27914 hydrochloride (CAS 184241-44-9)
See product citations (2)
Alternate Names:
5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N′-(2,4,6-trichlorophenyl)-4,6-pyrimidinediamine hydrochloride
Application:
NBI 27914 hydrochloride is a selective corticotropin-releasing factor 1 (CRF-RI) inhibitor
CAS Number:
184241-44-9
Purity:
>99%
Molecular Weight:
470.66
Molecular Formula:
C18H20Cl4N4•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NBI 27914 hydrochloride is a selective CRF-RI (type 1 corticotropin-releasing factor CR1) inhibitor. CRF-RI belongs to the family of CRF receptors, which are involved in modifying the autonomic, behavioral, and endocrine immune response to stress. Anterior pituitary studies indicate that NBI 27914 inhibits CRF-stimulation of cAMP and ACTH release. We supply the NBI 27914 hydrochloride form.
NBI 27914 hydrochloride (CAS 184241-44-9) References
- Recent advances with the CRF1 receptor: design of small molecule inhibitors, receptor subtypes and clinical indications. | McCarthy, JR., et al. 1999. Curr Pharm Des. 5: 289-315. PMID: 10213797
- Cortical sources of CRF, NKB, and CCK and their effects on pyramidal cells in the neocortex. | Gallopin, T., et al. 2006. Cereb Cortex. 16: 1440-52. PMID: 16339088
- Neonatal REM sleep is regulated by corticotropin releasing factor. | Feng, P., et al. 2007. Behav Brain Res. 182: 95-102. PMID: 17588683
- Distinct forms of Gq-receptor-dependent plasticity of excitatory transmission in the BNST are differentially affected by stress. | McElligott, ZA., et al. 2010. Proc Natl Acad Sci U S A. 107: 2271-6. PMID: 20133871
- Urocortin 1 reduces food intake and ghrelin secretion via CRF(2) receptors. | Yakabi, K., et al. 2011. Am J Physiol Endocrinol Metab. 301: E72-82. PMID: 21540451
- Predator Stress-Induced CRF Release Causes Enduring Sensitization of Basolateral Amygdala Norepinephrine Systems that Promote PTSD-Like Startle Abnormalities. | Rajbhandari, AK., et al. 2015. J Neurosci. 35: 14270-85. PMID: 26490866
- Lateral hypothalamus orexinergic system modulates the stress effect on pentylenetetrazol induced seizures through corticotropin releasing hormone receptor type 1. | Mokhtarpour, M., et al. 2016. Neuropharmacology. 110: 15-24. PMID: 27395784
- CRFR1 in the ventromedial caudate putamen modulates acute stress-enhanced expression of cocaine locomotor sensitization. | Liu, S., et al. 2017. Neuropharmacology. 121: 60-68. PMID: 28431969
- Tonic Suppression of the Mesolimbic Dopaminergic System by Enhanced Corticotropin-Releasing Factor Signaling Within the Bed Nucleus of the Stria Terminalis in Chronic Pain Model Rats. | Takahashi, D., et al. 2019. J Neurosci. 39: 8376-8385. PMID: 31451580
- Effects of stress-related peptides on chloride secretion in the mouse proximal colon. | Liu, S., et al. 2021. Neurogastroenterol Motil. 33: e14021. PMID: 33118282
- A role of noradrenergic receptors in anxiolytic-like effect of high CRF in the rat frontal cortex. | Śmiałowska, M., et al. 2021. Neuropeptides. 88: 102162. PMID: 34062382
- Lateral Hypothalamus Corticotropin-releasing Hormone Receptor-1 Inhibition and Modulating Stress-induced Anxiety Behavior. | Eghtesad, M., et al. 2022. Basic Clin Neurosci. 13: 373-384. PMID: 36457881
- The CRF1 receptor mediates the excitatory actions of corticotropin releasing factor (CRF) in the developing rat brain: in vivo evidence using a novel, selective, non-peptide CRF receptor antagonist. | Baram, TZ., et al. 1997. Brain Res. 770: 89-95. PMID: 9372207
Inhibitor of:
CRF-RI.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NBI 27914 hydrochloride, 10 mg | sc-204119 | 10 mg | $162.00 | |||
NBI 27914 hydrochloride, 50 mg | sc-204119A | 50 mg | $683.00 |