NBI 27914 hydrochloride CAS: 184241-44-9
MF: C18H20Cl4N4•HCl
MW: 470.66
A selective corticotropin-releasing factor 1 (CRF-RI) inhibitor.

NBI 27914 hydrochloride (CAS 184241-44-9)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 108ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: 5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)-4,6-pyrimidinediamine hydrochloride
Application: A selective corticotropin-releasing factor 1 (CRF-RI) inhibitor
CAS Number: 184241-44-9
Purity: >99%
Molecular Weight: 470.66
Molecular Formula: C18H20Cl4N4•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

NBI 27914 hydrochloride is a selective CRF-RI (type 1 corticotropin-releasing factor; CR1) inhibitor. CRF-RI belongs to the family of CRF receptors, which are involved in modifying the autonomic, behavioral, and endocrine immune response to stress. Anterior pituitary studies indicate that NBI 27914 inhibits CRF-stimulation of cAMP and ACTH release. We supply the NBI 27914 hydrochloride form.


1. Baram, T.Z., et al. 1997. T Brain Res. 770: 89-95. PMID: 9372207
2. McCarthy, J.R., et al. 1999. Curr. Pharm. Des. 5: 289-315. PMID: 10213797
3. McElligott, Z.A., et al. 2010. Proc. Natl. Acad. Sci. U.S.A. 107: 2271-2276. PMID: 20133871

Physical State :
Solubility :
Soluble in ethanol (100 mM), and DMSO (100 mM).
Storage :
Store at room temperature
Refractive Index :
n20D 1.65 (Predicted)
IC50 :
ACTH release: EC5050 = 70 nM (primary cultures of rat pituitary cells); CRF-stimulated cyclic adenosine monophosphate production: IC50 = 100 nM (human); Streptokinase A: EC5050 = 1.26 µM (Streptococcus pyogenes serotype M1); Streptococcus sp. 'group A': EC5050 = 1.39 µM; Plasmodium falciparum: IC50 = 3.16 µM
Ki Data :
CRF-RI: Ki= 1 nM (human); CRF1 receptor: Ki= 1.7 nM; Corticotropin releasing factor receptor: Ki= 2 nM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

What is the solubility of this product?

Asked by: hawkeye11
Thank you for your question. NBI 27914 hydrochloride, sc-204119, is soluble to 100 mM in DMSO and ethanol.
Answered by: TechService7
Date published: 2016-12-20
  • y_2020, m_3, d_31, h_13CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.5
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_204119, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 126ms
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 12ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.