NBI 27914 hydrochloride CAS: 184241-44-9
MF: C18H20Cl4N4•HCl
MW: 470.66
A selective corticotropin-releasing factor 1 (CRF-RI) inhibitor.

NBI 27914 hydrochloride (CAS 184241-44-9)

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Synonym: 5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)-4,6-pyrimidinediamine hydrochloride
Application: A selective corticotropin-releasing factor 1 (CRF-RI) inhibitor
CAS Number: 184241-44-9
Purity: >99%
Molecular Weight: 470.66
Molecular Formula: C18H20Cl4N4•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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NBI 27914 hydrochloride is a selective CRF-RI (type 1 corticotropin-releasing factor; CR1) inhibitor. CRF-RI belongs to the family of CRF receptors, which are involved in modifying the autonomic, behavioral, and endocrine immune response to stress. Anterior pituitary studies indicate that NBI 27914 inhibits CRF-stimulation of cAMP and ACTH release. We supply the NBI 27914 hydrochloride form.


References

1. Baram, T.Z., et al. 1997. T Brain Res. 770: 89-95. PMID: 9372207
2. McCarthy, J.R., et al. 1999. Curr. Pharm. Des. 5: 289-315. PMID: 10213797
3. McElligott, Z.A., et al. 2010. Proc. Natl. Acad. Sci. U.S.A. 107: 2271-2276. PMID: 20133871

Physical State :
Solid
Solubility :
Soluble in ethanol (100 mM), and DMSO (100 mM).
Storage :
Store at room temperature
Refractive Index :
n20D 1.65 (Predicted)
IC50 :
ACTH release: EC5050 = 70 nM (primary cultures of rat pituitary cells); CRF-stimulated cyclic adenosine monophosphate production: IC50 = 100 nM (human); Streptokinase A: EC5050 = 1.26 µM (Streptococcus pyogenes serotype M1); Streptococcus sp. 'group A': EC5050 = 1.39 µM; Plasmodium falciparum: IC50 = 3.16 µM
Ki Data :
CRF-RI: Ki= 1 nM (human); CRF1 receptor: Ki= 1.7 nM; Corticotropin releasing factor receptor: Ki= 2 nM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
UV8139455
PubChem CID :
45073446
MDL Number :
MFCD03791321
SMILES :
CCCN(CC1CC1)C2=NC(=NC(=C2Cl)NC3=C(C=C(C=C3Cl)Cl)Cl)C.Cl

Download SDS (MSDS)

Certificate of Analysis

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What is the solubility of this product?

Asked by: hawkeye11
Thank you for your question. NBI 27914 hydrochloride, sc-204119, is soluble to 100 mM in DMSO and ethanol.
Answered by: TechService7
Date published: 2016-12-20
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