NAT-5 Antibody (36-8): sc-100645

NAT-5 Antibody (36-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects NAT-5 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-NAT-5 antibody (36-8) is available as a non-conjugated monoclonal isotype antibody. NAT-5, also known as N-acetyltransferase 5 or NAA20, is a crucial 178 amino acid protein that plays a significant role in the N-terminal acetyltransferase B (NatB) complex, which is essential for the proper structure and function of actomyosin fibers, thereby facilitating effective cellular migration. NAT-5 contains one N-acetyltransferase domain and is involved in the cotranslational N-alpha-terminal acetylation of methionine residues that are followed by asparagine, a process vital for protein stability and function. NAT-5 is highly conserved across various species, including chimpanzees, dogs, cows, mice, rats, chickens, zebrafish, Drosophila, Caenorhabditis elegans, and Saccharomyces cerevisiae, highlighting its fundamental biological importance. In humans, NAT-5 is located on chromosome 20p11.23, underscoring its relevance in genetic studies and potential implications in oncogenesis and cell cycle regulation.

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NAT-5 Antibody (36-8) References:

1. The DNA sequence and comparative analysis of human chromosome 20.  |  Deloukas, P., et al. Nature. 414: 865-71. PMID: 11780052
2. NATH, a novel gene overexpressed in papillary thyroid carcinomas.  |  Fluge, Ø., et al. 2002. Oncogene. 21: 5056-68. PMID: 12140756
3. The yeast N(alpha)-acetyltransferase NatA is quantitatively anchored to the ribosome and interacts with nascent polypeptides.  |  Gautschi, M., et al. 2003. Mol Cell Biol. 23: 7403-14. PMID: 14517307
4. Cloning and characterization of hNAT5/hSAN: an evolutionarily conserved component of the NatA protein N-alpha-acetyltransferase complex.  |  Arnesen, T., et al. 2006. Gene. 371: 291-5. PMID: 16507339
5. Identification of the human N(alpha)-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression.  |  Starheim, KK., et al. 2008. Biochem J. 415: 325-31. PMID: 18570629
6. A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates.  |  Polevoda, B., et al. 2009. BMC Proc. 3 Suppl 6: S2. PMID: 19660095
7. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.  |  Van Damme, P., et al. 2012. Proc Natl Acad Sci U S A. 109: 12449-54. PMID: 22814378

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NAT-5 Antibody (36-8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-NAT-5 Antibody (36-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NAT-5 Antibody (36-8) Specifications

Alternate Product Name: NAT-5

Product Clone Name: 36-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-179

Epitope Target: NAT-5

Epitope Species: human

Product Reactivity/Detection: NAT-5

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for NAT-5 Antibody (36-8): N/A