Nargenicin A1 (CAS 70695-02-2)

Nargenicin A1, with the CAS number 70695-02-2, is a macrolide antibiotic that originates from a strain of the bacterium Nocardia. This compound is characterized by a large macrocyclic lactone ring, which is a common structural feature among macrolides. Nargenicin A1′s mechanism of action involves the inhibition of bacterial RNA polymerase, a crucial enzyme necessary for the transcription of RNA from DNA. By binding to this enzyme, nargenicin A1 effectively disrupts the process of gene expression within bacterial cells, leading to an inhibition of protein synthesis and ultimately bacterial growth. This mode of action makes nargenicin A1 an important compound for research, particularly in studies focused on bacterial gene expression and the development of resistance mechanisms. In the research domain, nargenicin A1 has been utilized to explore its unique binding and inhibition characteristics with RNA polymerase, offering insights into the potential design of new inhibitors that target this enzyme. Studies involving nargenicin A1 have contributed to a deeper understanding of the interaction between macrolide structures and bacterial transcription machinery, shedding light on the broader implications of antibiotic interference with cellular processes in pathogenic bacteria.