Napsin A Antibody (10C4B8): sc-517223

Napsin A Antibody (10C4B8) is a mouse monoclonal IgG1 antibody that detects the Napsin A protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Napsin A antibody (10C4B8) is available as the non-conjugated format. Napsin A is an aspartic proteinase belonging to the peptidase A1 family, crucial for the processing of surfactant proteins in pneumocytes, which are essential for maintaining surface tension in the alveoli and facilitating gas exchange in the lungs. Napsin A consists of 420 amino acids, including a 24-residue signal peptide, a 40-amino acid propeptide, a mature enzyme of 336 amino acids, and a C-terminal extension of 18 residues. Mature Napsin A features three predicted disulfide bonds and three potential N-linked oligosaccharide attachment sites, which are important for stability and function. Napsin A contains an RGD motif that serves as a recognition site for integrin binding, enhancing cell adhesion and signaling roles. Highest expression levels of Napsin A are found in adult lung type II pneumocytes, fetal lung, and kidney tissues, with lower levels detected in the adult spleen and minimal expression in peripheral blood leukocytes. Human Napsin A shares 72.6% sequence identity with mouse Napsin A, highlighting evolutionary conservation and significance in respiratory physiology.

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Napsin A Antibody (10C4B8) References:

1. Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas.  |  Chuman, Y., et al. 1999. FEBS Lett. 462: 129-34. PMID: 10580105
2. Surgical treatment of bone metastasis followed by a primary lung cancer lesion: report of a case.  |  Higashiyama, M., et al. 2004. Surg Today. 34: 600-5. PMID: 15221555
3. Pulmonary adenocarcinomas with enteric differentiation: histologic and immunohistochemical characteristics compared with metastatic colorectal cancers and usual pulmonary adenocarcinomas.  |  Inamura, K., et al. 2005. Am J Surg Pathol. 29: 660-5. PMID: 15832091
4. Napsins: new human aspartic proteinases. Distinction between two closely related genes.  |  Tatnell, PJ., et al. 1998. FEBS Lett. 441: 43-8. PMID: 9877162

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Napsin A Antibody (10C4B8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Napsin A Antibody (10C4B8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Napsin A Antibody (10C4B8) Specifications

Alternate Product Name: Napsin A

Product Clone Name: 10C4B8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 20-158

Epitope Target: Napsin A

Epitope Species: human

Product Reactivity/Detection: Napsin A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Napsin A Antibody (10C4B8): N/A