Molecular structure of Naphmethonium dibromide, CAS Number: 505059-27-8
Naphmethonium dibromide (CAS 505059-27-8)
Application:
Naphmethonium dibromide is a potent allosteric modulator of muscarinic receptors
CAS Number:
505059-27-8
Molecular Weight:
786.6
Molecular Formula:
C38H50Br2N4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Naphmethonium dibromide is a very potent allosteric modulator of muscarinic receptors, selective for M2-receptors. Retards the dissociation of the antagonist N-methylscopolamine and exhibits positive cooperativity, i.e. shows higher affinity for occupied receptors compared to free receptors. Naphmethonium dibromide′s affinity for the free receptor is about 100-fold higher than with W84. pKA =8.29, p(αKA)=8.66, pEC50,diss=8.36.
Naphmethonium dibromide (CAS 505059-27-8) References
Systematic development of high affinity bis(ammonio)alkane-type allosteric enhancers of muscarinic ligand binding: M. Muth, et al.; J. Med. Chem. 46, 1031 (2003) Design, Synthesis, and Action of Oxotremorine-Related Hybrid-Type Allosteric Modulators of Muscarinic Acetylcholine Receptors: T. Disingrini, et al.; J. Med. Chem. 49, 366 (2006)Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Naphmethonium dibromide, 5 mg | sc-202726 | 5 mg | $90.00 |