Date published: 2025-10-18

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Naphazoline Hydrochloride (CAS 550-99-2)

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Alternate Names:
2-(1-Naphthylmethyl)-2-imidazoline hydrochloride
Application:
Naphazoline Hydrochloride is a producer ionotropic effects via α-adrenoceptor stimulation
CAS Number:
550-99-2
Molecular Weight:
246.74
Molecular Formula:
C14H14N2•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Naphazoline hydrochloride produces ionotropic effects via α-adrenoceptor stimulation. Naphazoline Hydrochloride is an activator of AR and Nischarin.


Naphazoline Hydrochloride (CAS 550-99-2) References

  1. A comparison of the clinical efficacy of pheniramine maleate/naphazoline hydrochloride ophthalmic solution and olopatadine hydrochloride ophthalmic solution in the conjunctival allergen challenge model.  |  Greiner, JV. and Udell, IJ. 2005. Clin Ther. 27: 568-77. PMID: 15978305
  2. A rapid derivative spectrophotometric method for simultaneous determination of naphazoline and antazoline in eye drops.  |  Souri, E., et al. 2006. Chem Pharm Bull (Tokyo). 54: 119-22. PMID: 16394564
  3. Influence of the ageing phenomenon on the low-frequency electrical impedance behavior of naphazoline hydrochloride solutions and paracetamol syrup.  |  Brito, PC., et al. 2009. J Pharm Sci. 98: 1845-51. PMID: 18781632
  4. Flow-injection chemiluminescence method for the determination of naphazoline hydrochloride and oxymetazoline hydrochloride.  |  Wang, NN., et al. 2009. Luminescence. 24: 178-82. PMID: 19253271
  5. Spectroscopic analyses on interaction of Naphazoline hydrochloride with bovine serum albumin.  |  Zhu, S. and Liu, Y. 2012. Spectrochim Acta A Mol Biomol Spectrosc. 98: 142-7. PMID: 22995546
  6. Flow injection chemiluminescence determination of naphazoline hydrochloride in pharmaceuticals.  |  Iranifam, M. and Sorouraddin, MH. 2014. Luminescence. 29: 48-51. PMID: 23463582
  7. Report: Simultaneous determination of naphazoline hydrochloride, chlorpheniramine maleate and methylene blue in their ternary mixture.  |  Ali, NW., et al. 2013. Pak J Pharm Sci. 26: 641-8. PMID: 23625443
  8. A validated stability-indicating HPLC method for the simultaneous determination of pheniramine maleate and naphazoline hydrochloride in pharmaceutical formulations.  |  Huang, T., et al. 2014. Chem Cent J. 8: 7. PMID: 24485011
  9. Determination of naphazoline hydrochloride in biological and pharmaceutical samples by a quantum dot-assisted chemiluminescence system using response-surface methodology.  |  Imani-Nabiyyi, A. and Sorouraddin, MH. 2014. Luminescence. 29: 994-1002. PMID: 24733642
  10. Treatment with olopatadine and naphazoline hydrochloride reduces allergic conjunctivitis in mice through alterations in inflammation, NGF and VEGF.  |  Quan, L. and He, H. 2016. Mol Med Rep. 13: 3319-25. PMID: 26936233
  11. Stability Indicating UHPLC-PDA Assay for Simultaneous Determination of Antazoline Hydrochloride and Naphazoline Hydrochloride in Ophthalmic Formulations.  |  Ali, A., et al. 2017. Acta Chim Slov. 64: 332-341. PMID: 28621384
  12. In situ modified screen printed and carbon paste ion selective electrodes for potentiometric determination of naphazoline hydrochloride in its formulation.  |  Mohamed, GG., et al. 2013. J Pharm Anal. 3: 367-375. PMID: 29403841
  13. Evaluation of Gingival Displacement with Aluminum Chloride and Naphazoline Hydrochloride: A Randomized Controlled Trial.  |  de Carvalho, WF., et al. 2021. Eur J Prosthodont Restor Dent. 29: 47-53. PMID: 33026719
  14. A green TLC densitometric method for the simultaneous detection and quantification of naphazoline HCl, pheniramine maleate along with three official impurities.  |  Kelani, KM., et al. 2022. BMC Chem. 16: 24. PMID: 35379288

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Naphazoline Hydrochloride, 25 g

sc-205764
25 g
$49.00

Naphazoline Hydrochloride, 100 g

sc-205764A
100 g
$150.00