Nalpha-Fmoc-Nim-4-toluenesylfonyl-L-histidine (CAS 112380-10-6)

Nalpha-Fmoc-Nim-4-toluenesylfonyl-L-histidine is a compound that is widely used in the field of peptide chemistry for its protective group properties during the synthesis of peptides. The Fmoc (9-fluorenylmethoxycarbonyl) group on the amino terminus is acid-labile, allowing for its selective removal under mild conditions without affecting other sensitive functional groups. This feature is particularly important in solid-phase peptide synthesis, where stepwise construction of a peptide chain requires the protection and deprotection of amino acid residues. The 4-toluenesulfonyl group on the imidazole ring of histidine is another protective group that prevents unwanted side reactions at this site during the coupling of amino acid residues. Researchers utilize Nalpha-Fmoc-Nim-4-toluenesylfonyl-L-histidine to study the synthesis of histidine-containing peptides, investigating the stability and reactivity of the protective groups and optimizing the conditions for efficient peptide assembly.