Nalpha-Boc-Nin-mesitylene-2-sulfonyl-L-tryptophan dicyclohexylammonium salt (CAS 92916-48-8)

Nalpha-Boc-Nin-mesitylene-2-sulfonyl-L-tryptophan dicyclohexylammonium salt (NBMTS) is a significant compound in the field of organic chemistry, derived from tryptophan with an alkyl substituent on the nitrogen atom and a sulfonamide group on the β-carbon atom. Its versatility enables a wide range of applications in both organic synthesis and scientific research. Nalpha-Boc-Nin-mesitylene-2-sulfonyl-L-tryptophan dicyclohexylammonium salt finds extensive use in scientific research, serving as a substrate for the enzyme trypsin, a ligand for proteins, and a probe for studying protein-protein interactions. It also contributes to the development of enzyme inhibitors, including those targeting cytochrome P450 and proteases.. The precise mechanism of action of Nalpha-Boc-Nin-mesitylene-2-sulfonyl-L-tryptophan dicyclohexylammonium salt remains under investigation. It is hypothesized that the sulfonamide group of Nalpha-Boc-Nin-mesitylene-2-sulfonyl-L-tryptophan dicyclohexylammonium salt binds to the active site of enzymes, while the alkyl substituent on the nitrogen atom binds to the protein, facilitating the formation of a covalent bond between the two. This covalent bond is believed to be responsible for inhibiting enzyme activity.