Date published: 2025-10-15

1-800-457-3801

SCBT Portrait Logo
Seach Input

Naloxone methiodide (CAS 93302-47-7)

0.0(0)
Write a reviewAsk a question

See product citations (1)

Alternate Names:
N-Methylnaloxonium iodide
Application:
Naloxone methiodide is a nonselective antagonist
CAS Number:
93302-47-7
Purity:
≥98%
Molecular Weight:
469.31
Molecular Formula:
C20H24INO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Naloxone methiodide, a chemical compound, functions as an opioid antagonist, akin to naloxone. It serves as a quaternary ammonium salt, rendering it more water-soluble than naloxone and thus more suitable for specific applications.The compound finds widespread use in scientific research, particularly in investigating opioid receptors. Naloxone methiodide facilitates the study of opioid binding to these receptors and the impact of opioid antagonists on them.Naloxone methiodide operates similarly to naloxone by binding to opioid receptors and thwarting opioid effects. As an antagonist, it does not activate these receptors but rather inhibits other molecules from activating them. Notably, it exhibits a higher affinity for the mu-opioid receptor than the delta- and kappa-opioid receptors, making it particularly effective in blocking the effects of mu-opioid agonists.


Naloxone methiodide (CAS 93302-47-7) References

  1. Paraventricular nucleus injections of naloxone methiodide inhibit NPY's effects on energy substrate utilization.  |  Currie, PJ., et al. 2000. Neuroreport. 11: 733-5. PMID: 10757510
  2. Naloxone methiodide reverses opioid-induced respiratory depression and analgesia without withdrawal.  |  Lewanowitsch, T. and Irvine, RJ. 2002. Eur J Pharmacol. 445: 61-7. PMID: 12065195
  3. Naloxone and its quaternary derivative, naloxone methiodide, have differing affinities for mu, delta, and kappa opioid receptors in mouse brain homogenates.  |  Lewanowitsch, T. and Irvine, RJ. 2003. Brain Res. 964: 302-5. PMID: 12576191
  4. Morphine withdrawal-induced c-fos expression in the heart: a peripheral mechanism.  |  González-Cuello, A., et al. 2004. Eur J Pharmacol. 487: 117-24. PMID: 15033383
  5. Reversal of morphine, methadone and heroin induced effects in mice by naloxone methiodide.  |  Lewanowitsch, T., et al. 2006. Life Sci. 78: 682-8. PMID: 16102783
  6. Central effects of morphine on GI motility in conscious dogs.  |  Takahashi, T., et al. 2007. Brain Res. 1166: 29-34. PMID: 17669372
  7. Infusions of naloxone into the medial preoptic area, ventromedial nucleus of the hypothalamus, and amygdala block conditioned place preference induced by paced mating behavior.  |  García-Horsman, SP., et al. 2008. Horm Behav. 54: 709-16. PMID: 18721808
  8. Effects of ICI204,448, naloxone methiodide and levocetirizine on the scratching behavior induced by a κ-opioid antagonist, nor-BNI, in ICR mice.  |  Nakasone, T., et al. 2017. Immunopharmacol Immunotoxicol. 39: 292-295. PMID: 28745076
  9. TRPV1 promotes opioid analgesia during inflammation.  |  Basso, L., et al. 2019. Sci Signal. 12: PMID: 30940767
  10. The Role of Peripheral Opioid Receptors in Triggering Heroin-induced Brain Hypoxia.  |  Perekopskiy, D., et al. 2020. Sci Rep. 10: 833. PMID: 31964994
  11. Naloxone regulates the differentiation of neural stem cells via a receptor-independent pathway.  |  Chen, J., et al. 2020. FASEB J. 34: 5917-5930. PMID: 32154623
  12. Central opioid receptors mediate morphine-induced itch and chronic itch via disinhibition.  |  Wang, Z., et al. 2021. Brain. 144: 665-681. PMID: 33367648
  13. Potential role of ghrelin on the micturition reflex in rats.  |  Honda, M., et al. 2021. Cent European J Urol. 74: 185-189. PMID: 34336236
  14. Peripheral effects of naloxone in mice with acute diarrhea associated with intestinal inflammation.  |  Pol, O., et al. 1995. J Pharmacol Exp Ther. 272: 1271-6. PMID: 7891343

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Naloxone methiodide, 25 mg

sc-255387
25 mg
$97.00
US: Only available in the US

Naloxone methiodide, 100 mg

sc-255387A
100 mg
$280.00
US: Only available in the US

Naloxone methiodide, 250 mg

sc-255387B
250 mg
$578.00
US: Only available in the US