Molecular structure of Naloxone hydrochloride, CAS Number: 357-08-4
Naloxone hydrochloride (CAS 357-08-4)
See product citations (2)
Alternate Names:
(5α)-17-allyl-4,5-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
Application:
Naloxone hydrochloride is a nonspecific opiate receptor antagonist that displays anitnociceptive effects
CAS Number:
357-08-4
Molecular Weight:
363.84
Molecular Formula:
C19H21NO4•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Naloxone hydrochloride is a compound that is widely used in research related to neurochemistry and the study of opioid receptors. As a competitive antagonist for these receptors, naloxone hydrochloride is useful in experiments designed to understand the binding characteristics and signaling pathways of opioid peptides and other ligands. Research using naloxone hydrochloride often involves the assessment of receptor-ligand interactions within the central nervous system and the elucidation of the endogenous opioid system′s role in regulating physiological processes. Additionally, the compound is used to study the mechanisms of action of various substances that influence the opioid receptors, providing valuable insights into receptor dynamics and potential modulation strategies.
Naloxone hydrochloride (CAS 357-08-4) References
- Effects of acute low-dose combined treatment with naloxone and AM 251 on food intake, feeding behaviour and weight gain in rats. | Tallett, AJ., et al. 2009. Pharmacol Biochem Behav. 91: 358-66. PMID: 18755211
- Development and validation of a HPLC method for the determination of buprenorphine hydrochloride, naloxone hydrochloride and noroxymorphone in a tablet formulation. | Mostafavi, A., et al. 2009. Talanta. 77: 1415-9. PMID: 19084658
- Naloxone can improve the anti-tumor immunity by reducing the CD4+CD25+Foxp3+ regulatory T cells in BALB/c mice. | Molla Hassan, AT., et al. 2009. Int Immunopharmacol. 9: 1381-6. PMID: 19706340
- Role of intravenous naloxone in severe pruritus of acute cholestasis. | Joshi, GG., et al. 2009. Indian J Gastroenterol. 28: 180-2. PMID: 20107967
- America's Opioid Epidemic: a Comprehensive Review and Look into the Rising Crisis. | Ostling, PS., et al. 2018. Curr Pain Headache Rep. 22: 32. PMID: 29619569
- Epidural versus non-epidural or no analgesia for pain management in labour. | Anim-Somuah, M., et al. 2018. Cochrane Database Syst Rev. 5: CD000331. PMID: 29781504
- Abuse of fentanyl: An emerging problem to face. | Kuczyńska, K., et al. 2018. Forensic Sci Int. 289: 207-214. PMID: 29902699
- Methylnaltrexone bromide for the treatment of opioid-induced constipation. | Mozaffari, S., et al. 2018. Expert Opin Pharmacother. 19: 1127-1135. PMID: 29979903
- Naloxone Academic Detailing: Role of Community Outreach Teaching. | Abd-Elsayed, A., et al. 2018. Curr Pain Headache Rep. 22: 72. PMID: 30151695
- The effects of heat and freeze-thaw cycling on naloxone stability. | Lai, D., et al. 2019. Harm Reduct J. 16: 17. PMID: 30813917
- Pharmacokinetics and pharmacodynamics of intranasal and intravenous naloxone hydrochloride administration in healthy dogs. | Wahler, BM., et al. 2019. Am J Vet Res. 80: 696-701. PMID: 31246123
- Microneedle-mediated transdermal delivery of naloxone hydrochloride for treatment of opioid overdose. | Puri, A., et al. 2021. Int J Pharm. 604: 120739. PMID: 34048932
- New and experimental therapeutic roles for naloxone and related opioid antagonists. | McNicholas, LF. and Martin, WR. 1984. Drugs. 27: 81-93. PMID: 6319107
Inhibitor of:
DOR, KOR, MOR, and Sigma Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Naloxone hydrochloride, 50 mg | sc-203153 | 50 mg | $87.00 | |||
| US: Only available in the US | ||||||
Naloxone hydrochloride, 100 mg | sc-203153A | 100 mg | $169.00 | |||
| US: Only available in the US | ||||||
Naloxone hydrochloride, 1 g | sc-203153B | 1 g | $342.00 | |||
| US: Only available in the US | ||||||
Naloxone hydrochloride, 10 g | sc-203153C | 10 g | $1864.00 | |||
| US: Only available in the US | ||||||