Date published: 2026-4-19

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Nalidixic acid sodium salt (CAS 3374-05-8)

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Alternate Names:
1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid sodium salt
Application:
Nalidixic acid sodium salt is A synthetic 1,8-naphthyridine antimicrobial agent
CAS Number:
3374-05-8
Purity:
≥95%
Molecular Weight:
254.22
Molecular Formula:
C12H11N2NaO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Nalidixic acid sodium salt is a chemical compound that has garnered interest in the field of microbiology, specifically in studies related to bacterial DNA replication. It is recognized as an inhibitor of bacterial DNA gyrase, an enzyme critical for supercoiling DNA, which is a necessary step in DNA replication. Research involving Nalidixic acid sodium salt often explores the dynamics of bacterial growth and the molecular mechanisms that lead to the inhibition of DNA synthesis. The compound is used to decipher the processes by which certain bacteria may develop resistance to DNA gyrase inhibitors, which is an important aspect of understanding how to control bacterial populations. Additionally, Nalidixic acid sodium salt serves as a tool in the study of mutagenesis, as it can induce mutations in the DNA of susceptible bacteria, thereby aiding in the investigation of genetic variability and adaptation in microbial systems.


Nalidixic acid sodium salt (CAS 3374-05-8) References

  1. Effect of genomic location on horizontal transfer of a recombinant gene cassette between Pseudomonas strains in the rhizosphere and spermosphere of barley seedlings.  |  Sengeløv, G., et al. 2001. Curr Microbiol. 42: 160-7. PMID: 11270648
  2. Studies on molecular interactions between nalidixic acid and liposomes.  |  Budai, M., et al. 2004. Int J Pharm. 279: 67-79. PMID: 15234796
  3. Some observations on the diffusion of antimicrobial agents through the retention balloons of foley catheters.  |  Williams, GJ. and Stickler, DJ. 2007. J Urol. 178: 697-701. PMID: 17574612
  4. Traditional methods for isolation of Listeria monocytogenes.  |  Magalhães, R., et al. 2014. Methods Mol Biol. 1157: 15-30. PMID: 24792545
  5. Traditional Methods of Analysis for Listeria monocytogenes.  |  Magalhães, R., et al. 2021. Methods Mol Biol. 2220: 3-16. PMID: 32975762
  6. Streptomycin and nalidixic acid elevate the spontaneous genome-wide mutation rate in Escherichia coli.  |  Ozdemirel, HO., et al. 2021. Genetica. 149: 73-80. PMID: 33502702
  7. Design of an Antibiotic-Releasing Polymer: Physicochemical Characterization and Drug Release Patterns.  |  Padinjarathil, H., et al. 2023. Membranes (Basel). 13: PMID: 36676910
  8. Enhanced delivery of nalidixic acid through human skin via acyloxymethyl ester prodrugs  |  Bundgaard, H., Mørk, N., & Hoelgaard, A. 1989. International journal of pharmaceutics. 55(2-3): 91-97.
  9. Thermal inactivation of Salmonella spp. and Listeria innocua in the chicken breast patties processed in a pilot‐scale air‐convection oven  |  Murphy, R. Y., Johnson, E. R., Duncan, L. K., Davis, M. D., Johnson, M. G., & Marcy, J. A. 2001. Journal of food science. 66(5): 734-741.
  10. Thermal inactivation of Salmonella Senftenberg and Listeria innocua in beef/turkey blended patties cooked via fryer and/or air convection oven  |  Murphy, R. Y., Duncan, L. K., Johnson, E. R., Davis, M. D., & Marcy, J. A. 2002. Journal of food science. 67(5): 1879-1885.
  11. Effect of packaging‐film thicknesses on thermal inactivation of Salmonella and Listeria innocua in fully cooked chicken breast meat  |  Murphy, R. Y., Duncan, L. K., Marcy, J. A., Berrang, M. E., & Driscoll, K. H. 2002. Journal of food science,. 67(9): 3435-3440.
  12. Polypropylene grafted with NIPAAm and APMA for creating hemocompatible surfaces that load/elute nalidixic acid  |  Contreras-García, A., Bucio, E., Concheiro, A., & Alvarez-Lorenzo, C. 2010. Reactive and Functional Polymers. 70(10): 836-842.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Nalidixic acid sodium salt, 1 g

sc-215532A
1 g
$20.00

Nalidixic acid sodium salt, 5 g

sc-215532
5 g
$51.00