Nalidixic acid (CAS 389-08-2)
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Nalidixic acid is a pioneering synthetic compound within the quinolone antibiotic class, notable for its action against a variety of bacterial agents by targeting the DNA gyrase enzyme critical for bacterial DNA replication and repair. This specific mechanism disrupts the supercoiling of bacterial DNA, effectively halting DNA synthesis and impeding bacterial proliferation. Predominantly, nalidixic acid showcases efficacy against gram-negative organisms, including select Escherichia coli strains and members of the Enterobacteriaceae family, although its effectiveness is somewhat circumscribed when juxtaposed with newer quinolone derivatives, showing limited activity against gram-positive bacteria. Its historical significance lies in its role as an early synthetic quinolone antibiotic, though its application has been curtailed over time due to its narrow activity spectrum and the advent of bacterial resistance.
Nalidixic acid (CAS 389-08-2) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nalidixic acid, 5 g | sc-219324 | 5 g | $43.00 | |||
Nalidixic acid, 25 g | sc-219324A | 25 g | $75.00 |