Naftifine, Hydrochloride (CAS 65473-14-5)

Naftifine hydrochloride, with the CAS number 65473-14-5, is a synthetic allylamine compound known for its antifungal properties. The effectiveness of naftifine hydrochloride arises from its ability to interfere with the biosynthesis of ergosterol, an essential component of fungal cell membranes. It achieves this by inhibiting the enzyme squalene epoxidase, which is a key player in the ergosterol synthesis pathway. This inhibition leads to a deficiency in ergosterol and an accumulation of squalene within the fungal cells, disrupting cell membrane integrity and ultimately resulting in fungal cell death. The specific action of naftifine hydrochloride on squalene epoxidase makes it a valuable tool in the study of fungal metabolism and cell structure, providing insights into fungal growth and reproduction mechanisms. Moreover, its unique mechanism has made naftifine hydrochloride a subject of interest in research focusing on the development of resistance to antifungal agents. Studies involving this compound help in understanding how fungi evolve resistance to ergosterol synthesis inhibitors and what strategies might be effective in overcoming this resistance. Additionally, naftifine hydrochloride is used in environmental and agricultural research to explore its efficacy and safety as a fungicide, particularly in controlling fungal pathogens that affect crops.