Molecular structure of Nafoxidine hydrochloride, CAS Number: 1847-63-8
Nafoxidine hydrochloride (CAS 1847-63-8)
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Alternate Names:
1-[2-[4-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthalenyl)phenoxy]ethyl]pyrrolidine Hydrochloride
CAS Number:
1847-63-8
Molecular Weight:
462.02
Molecular Formula:
C29H31NO2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Nafoxidine hydrochloride is used in biochemical, where its interaction with various receptors is studied to understand receptor binding dynamics and specificity. It is particularly in the investigation of estrogen receptor interactions, providing insights into receptor modulation and signal transduction pathways. In molecular biology, Nafoxidine hydrochloride is utilized to examine the expression of genes regulated by estrogen receptors, aiding in the understanding of gene regulation mechanisms under various physiological conditions.We also employ Nafoxidine hydrochloride in studies focused on cellular response to receptor activity, which includes examining changes in cell proliferation and apoptosis. it is used in the development of assays that assess the binding affinity and activity of compounds on estrogen receptors, contributing to advancements in methodologies and assay development.
Nafoxidine hydrochloride (CAS 1847-63-8) References
- Nafoxidine modulates the expression of matrix-metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinases-1 (TIMP-1) in endothelial cells. | De Lorenzo, MS., et al. 2000. Anticancer Res. 20: 395-400. PMID: 10769686
- Inhibition of volume-regulated anion channels in cultured endothelial cells by the anti-oestrogens clomiphene and nafoxidine. | Maertens, C., et al. 2001. Br J Pharmacol. 132: 135-42. PMID: 11156570
- Role of protein kinase C-dependent signaling pathways in the antiangiogenic properties of nafoxidine. | De Lorenzo, MS., et al. 2004. Anticancer Res. 24: 1737-43. PMID: 15274349
- Comparison of the antiproliferative properties of antiestrogenic drugs (nafoxidine and clomiphene) on glioma cells in vitro. | Yaz, G., et al. 2004. Am J Clin Oncol. 27: 384-8. PMID: 15289732
- Female steroid hormones and lipoprotein synthesis in the cockerel: effects of progesterone and nafoxidine on the estrogenic stimulation of very low density lipoproteins (VLDL) synthesis. | Chan, L., et al. 1977. Endocrinology. 100: 1636-43. PMID: 192542
- Development of concise two-step catalytic approach towards lasofoxifene precursor nafoxidine. | Johansson Seechurn, CCC., et al. 2018. Bioorg Med Chem. 26: 2691-2697. PMID: 29678534
- Effect of neonatal exposure to the antioestrogens nafoxidine and CI-628 upon the development of the uterus in the prepubertal rat. | Campbell, PS. and Satterfield, PM. 1988. J Reprod Fertil. 83: 225-31. PMID: 3397940
- Nafoxidine possesses antitumor activity against an ascitic hepatoma. | Khar, A. 1986. Eur J Cancer Clin Oncol. 22: 1475-8. PMID: 3595673
- Nafoxidine administered to newborn female GR mice arrests the development of their mammary glands. | Strum, JM. 1983. Virchows Arch B Cell Pathol Incl Mol Pathol. 42: 227-33. PMID: 6133394
- Nafoxidine-responsive uterine protein: further characterization and distinction from the 'estrogen-induced' protein (IP). | Mairesse, N., et al. 1981. Mol Cell Endocrinol. 24: 53-63. PMID: 6173271
- Induction of cryptic lactogenic hormone binding in livers of adult female mice treated neonatally with estradiol or nafoxidine. | Alhadi, T. and Vonderhaar, BK. 1982. Endocrinology. 110: 254-9. PMID: 6274621
- Time-course of the effects of nafoxidine and oestradiol on separate groups of responses in the uterus of the immature rat. | Galand, P., et al. 1984. J Steroid Biochem. 21: 43-7. PMID: 6748655
- Effects of nafoxidine on the luteinizing hormone surge: temporal distribution of estrogen receptors and induction of cytoplasmic progestin receptors in the hypothalamus-preoptic area, pituitary, and uterus of the immature rat. | Attardi, B. and Palumbo, LA. 1981. Endocrinology. 109: 1365-74. PMID: 7297482
- Raloxifene, tamoxifen, nafoxidine, or estrogen effects on reproductive and nonreproductive tissues in ovariectomized rats. | Sato, M., et al. 1996. FASEB J. 10: 905-12. PMID: 8666168
- Interaction of the anti-oestrogen, nafoxidine hydrochloride, with the soluble nuclear oestradiol-binding protein in chick liver. | Lazier, CB. and Alford, WS. 1977. Biochem J. 164: 659-67. PMID: 883957
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nafoxidine hydrochloride, 5 mg | sc-477797 | 5 mg | $224.00 |