NaDC-3 Antibody (3A6): sc-293347
- NaDC-3 Antibody (3A6) is a mouse monoclonal IgG2a κ NaDC-3 antibody provided at 100 µg/ml
- raised against amino acids 152-232 of NaDC-3 of human origin
- recommended for detection of NaDC-3 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NaDC-3 Antibody (3A6). This work is in progress.
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NaDC-3 Antibody (3A6) is a mouse monoclonal IgG2a kappa light chain antibody that detects NaDC-3 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-NaDC-3 antibody (3A6) is available as a non-conjugated format. NaDC-3, also known as SLC13A3 or sodium-dependent high-affinity dicarboxylate transporter 2, is a crucial 602 amino acid multi-pass membrane protein that plays a significant role in the transport of sodium and dicarboxylate substrates, such as succinate and citrate, across the plasma membrane. NaDC-3 is essential for maintaining cellular homeostasis and energy metabolism, as NaDC-3 facilitates the uptake of key Krebs cycle intermediates, which are vital for cellular respiration and energy production. The gene encoding human NaDC-3 is located on chromosome 20 and is predominantly expressed in the kidney, liver, placenta, brain, and pancreas, highlighting its importance in various physiological processes. NaDC-3 (3A6) monoclonal antibody is an invaluable tool for researchers studying the functional dynamics of NaDC-3 in human tissues and its implications in metabolic disorders.
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NaDC-3 Antibody (3A6) References:
- Sodium-coupled transporters for Krebs cycle intermediates. | Pajor, AM. 1999. Annu Rev Physiol. 61: 663-82. PMID: 10099705
- Structure, function, and genomic organization of human Na(+)-dependent high-affinity dicarboxylate transporter. | Wang, H., et al. 2000. Am J Physiol Cell Physiol. 278: C1019-30. PMID: 10794676
- Transport of N-acetylaspartate by the Na(+)-dependent high-affinity dicarboxylate transporter NaDC3 and its relevance to the expression of the transporter in the brain. | Huang, W., et al. 2000. J Pharmacol Exp Ther. 295: 392-403. PMID: 10992006
- The SLC13 gene family of sodium sulphate/carboxylate cotransporters. | Markovich, D. and Murer, H. 2004. Pflugers Arch. 447: 594-602. PMID: 12915942
- Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters. | Pajor, AM. 2006. Pflugers Arch. 451: 597-605. PMID: 16211368
- Identification of basolateral membrane targeting signal of human sodium-dependent dicarboxylate transporter 3. | Bai, X., et al. 2006. J Cell Physiol. 206: 821-30. PMID: 16331647
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NaDC-3 Antibody (3A6) | sc-293347 | 100 µg/ml | $316.00 |