NAALADL2 Antibody (1G5): sc-517173

NAALADL2 Antibody (1G5) is a mouse monoclonal IgG2a kappa light chain antibody that detects NAALADL2 of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-NAALADL2 antibody (1G5) is available as a non-conjugated monoclonal isotype antibody. NAALADL2, or N-acetylated alpha-linked acidic dipeptidase-like 2, is a 795 amino acid single-pass type II membrane protein that belongs to the peptidase M28 family and M28B subfamily. NAALADL2 is primarily located in the cell membrane, which is crucial for potential role in cellular signaling and interaction with extracellular substrates. Membrane localization allows NAALADL2 to participate in various physiological processes, including neuropeptide metabolism and modulation of synaptic transmission, which are vital for maintaining normal neurological function. NAALADL2 exists in two alternatively spliced isoforms and is predominantly expressed in the placenta and kidney, with additional expression noted in certain embryonic tissues. The gene encoding NAALADL2 is situated on human chromosome 3, a region associated with numerous genetic diseases and key tumor suppressor genes, highlighting potential implications of NAALADL2 in both health and disease.

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NAALADL2 Antibody (1G5) References:

1. The molecular genetics of Marfan syndrome and related microfibrillopathies.  |  Robinson, PN. and Godfrey, M. 2000. J Med Genet. 37: 9-25. PMID: 10633129
2. Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome.  |  Maho, A., et al. 1999. Cytogenet Cell Genet. 87: 265-8. PMID: 10702689
3. [New tumor suppressor genes in hot spots of human chromosome 3: new methods of identification].  |  Braga, EA., et al. 2003. Mol Biol (Mosk). 37: 194-211. PMID: 12723467
4. Plasticity of human chromosome 3 during primate evolution.  |  Tsend-Ayush, E., et al. 2004. Genomics. 83: 193-202. PMID: 14706448
5. A giant novel gene undergoing extensive alternative splicing is severed by a Cornelia de Lange-associated translocation breakpoint at 3q26.3.  |  Tonkin, ET., et al. 2004. Hum Genet. 115: 139-48. PMID: 15168106
6. Comparative cytogenetics of human chromosome 3q21.3 reveals a hot spot for ectopic recombination in hominoid evolution.  |  Yue, Y., et al. 2005. Genomics. 85: 36-47. PMID: 15607420
7. Methylation of the tumor suppressor gene RASSF1A in human tumors.  |  Pfeifer, GP. and Dammann, R. 2005. Biochemistry (Mosc). 70: 576-83. PMID: 15948711
8. High-resolution analysis of 3p deletion in neuroblastoma and differential methylation of the SEMA3B tumor suppressor gene.  |  Nair, PN., et al. 2007. Cancer Genet Cytogenet. 174: 100-10. PMID: 17452250
9. Mutilating neuropathic ulcerations in a chromosome 3q13-q22 linked Charcot-Marie-Tooth disease type 2B family.  |  De Jonghe, P., et al. 1997. J Neurol Neurosurg Psychiatry. 62: 570-3. PMID: 9219740

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NAALADL2 Antibody (1G5) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-NAALADL2 Antibody (1G5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NAALADL2 Antibody (1G5) Specifications

Alternate Product Name: NAALADL2

Product Clone Name: 1G5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 696-795

Epitope Target: NAALADL2

Epitope Species: human

Product Reactivity/Detection: NAALADL2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for NAALADL2 Antibody (1G5): N/A