Na⁺ CP type VIIIα Antibody (W-78): sc-81884

Na+ CP type VIIIα Antibody (W-78) is a mouse monoclonal IgG2a kappa light chain antibody that detects Na+ CP type VIIIα protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Na+ CP type VIIIα antibody (W-78) is available as the non-conjugated form. Sodium channel protein type 8 subunit alpha (Na+ CP type VIIIα) is a multi-pass transmembrane protein that plays a crucial role in mediating sodium ion permeability across excitable membranes, essential for generating and propagating action potentials in neurons. Na+ CP type VIIIα is part of a larger family of voltage-gated sodium channels, including a pore-forming alpha subunit and two noncovalently associated beta subunits vital for channel expression and function. Na+ CP type VIIIα is predominantly expressed in neuronal cell bodies and proximal processes, while beta subunits contribute to channel gating modulation and serve as cell adhesion molecules, facilitating cellular aggregation and cytoskeleton interaction. Proper functioning of Na+ CP type VIIIα is critical for rapid signal transduction and neuronal development; defects in the SCN8A gene, which encodes Na+ CP type VIIIα, have been linked to severe consequences such as progressive paralysis and early mortality due to impaired neuronal growth.

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Na⁺ CP type VIIIα Antibody (W-78) References:

1. Gene symbol: SCN8A. Disease: Ataxia. Accession #Hd0520.  |  Meisler, MH., et al. 2006. Hum Genet. 118: 776. PMID: 17297687
2. Sodium channel expression within chronic multiple sclerosis plaques.  |  Black, JA., et al. 2007. J Neuropathol Exp Neurol. 66: 828-37. PMID: 17805013
3. The voltage-gated sodium channel Scn8a is a genetic modifier of severe myoclonic epilepsy of infancy.  |  Martin, MS., et al. 2007. Hum Mol Genet. 16: 2892-9. PMID: 17881658
4. Identification of evolutionarily conserved, functional noncoding elements in the promoter region of the sodium channel gene SCN8A.  |  Drews, VL., et al. 2007. Mamm Genome. 18: 723-31. PMID: 17924165
5. Comparison of gamma-aminobutyrate receptors in the medial vestibular nucleus of control and Scn8a mutant mice.  |  Sun, Y., et al. 2007. Brain Res. 1186: 188-93. PMID: 17999925
6. Voltage-dependent Na(v)1.7 sodium channels: multiple roles in adrenal chromaffin cells and peripheral nervous system.  |  Wada, A., et al. 2008. Acta Physiol (Oxf). 192: 221-31. PMID: 18021327
7. Nav1.6 sodium channels are critical to pacemaking and fast spiking in globus pallidus neurons.  |  Mercer, JN., et al. 2007. J Neurosci. 27: 13552-66. PMID: 18057213
8. Molecular and biophysical properties of voltage-gated Na+ channels in murine vas deferens.  |  Zhu, HL., et al. 2008. Biophys J. 94: 3340-51. PMID: 18192366
9. Exaggerated emotional behavior in mice heterozygous null for the sodium channel Scn8a (Nav1.6).  |  McKinney, BC., et al. 2008. Genes Brain Behav. 7: 629-38. PMID: 18363861
10. ATP1A2- and ATP1A3-associated early profound epileptic encephalopathy and polymicrogyria.  |  Vetro, A., et al. 2021. Brain. 144: 1435-1450. PMID: 33880529
11. The Phenotypic Continuum of ATP1A3-Related Disorders.  |  Vezyroglou, A., et al. 2022. Neurology. 99: e1511-e1526. PMID: 36192182
12. ATP1A3 as a target for isolating neuron-specific extracellular vesicles from human brain and biofluids.  |  You, Y., et al. 2023. Sci Adv. 9: eadi3647. PMID: 37713494

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Na⁺ CP type VIIIα Antibody (W-78) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Na⁺ CP type VIIIα Antibody (W-78) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Na⁺ CP type VIIIα Antibody (W-78) Specifications

Alternate Product Name: Na+ CP type VIIIα

Product Clone Name: W-78

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1854-1952

Epitope Target: Na⁺ CP type VIIIα

Epitope Species: human

Product Reactivity/Detection: Na+ CP type VIIIα

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Na⁺ CP type VIIIα Antibody (W-78): N/A