Na+ CP type Vα Antibody (4G8:1G7): sc-81631
- Na+ CP type Vα Antibody (4G8:1G7) is a mouse monoclonal IgG1, cited in 1 publications, provided at 200 µg/ml
- raised against a synthetic peptide corresponding to an extracellular region of Na+ CP type Vα of human origin
- recommended for detection of Voltage-gated sodium channel subunit α Nav1.5 of human origin by WB and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Na+ CP type Vα Antibody (4G8:1G7). This work is in progress.
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Na+ CP type Vα Antibody (4G8:1G7) is a mouse monoclonal IgG1 antibody that detects Na+ CP type Vα in human samples through applications such as western blotting (WB) and immunofluorescence (IF). Na+ CP type Vα, encoded by the SCN5A gene located on chromosome 3q21-24, plays a crucial role in the cardiac action potential by facilitating the initial depolarization phase, which is essential for the proper conduction of electrical signals through the heart. Na+ CP type Vα is primarily expressed in human atrial and ventricular cardiac muscle, where Na+ CP type Vα contributes to the regulation of sodium ion flow across the cell membrane, thereby influencing heart rhythm and contractility. Mutations in the SCN5A gene can lead to various cardiac arrhythmias, including Brugada syndrome and long QT syndrome type III, highlighting Na+ CP type Vα′s significance in maintaining cardiac health. Anti-Na+ CP type Vα antibody (4G8:1G7) serves as an invaluable tool for researchers studying cardiac function and the molecular mechanisms underlying arrhythmias, providing insights into both normal physiology and pathological conditions.
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Na+ CP type Vα Antibody (4G8:1G7) References:
- Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination. | van Bemmelen, MX., et al. 2004. Circ Res. 95: 284-91. PMID: 15217910
- Regulation of the voltage-gated cardiac sodium channel Nav1.5 by interacting proteins. | Abriel, H. and Kass, RS. 2005. Trends Cardiovasc Med. 15: 35-40. PMID: 15795161
- Immunohistochemical marker for Na+ CP type Valpha (C-20) and heterozygous nonsense SCN5A mutation W822X in a sudden cardiac death induced by mild anaphylactic reaction. | Turillazzi, E., et al. 2009. Appl Immunohistochem Mol Morphol. 17: 357-62. PMID: 19318916
- Unexpected α-α interactions with NaV1.5 genetic variants in Brugada syndrome. | Abriel, H. and Sottas, V. 2014. Circ Cardiovasc Genet. 7: 97-9. PMID: 24736849
- Regulation of the cardiac Na+ channel NaV1.5 by post-translational modifications. | Marionneau, C. and Abriel, H. 2015. J Mol Cell Cardiol. 82: 36-47. PMID: 25748040
- Structural basis of cytoplasmic NaV1.5 and NaV1.4 regulation. | Nathan, S., et al. 2021. J Gen Physiol. 153: PMID: 33306788
- Tbx5 variants disrupt Nav1.5 function differently in patients diagnosed with Brugada or Long QT Syndrome. | Nieto-Marín, P., et al. 2022. Cardiovasc Res. 118: 1046-1060. PMID: 33576403
- Ethnic-Related Sodium Voltage-Gated Channel α Subunit 5 Polymorphisms Shape the In Vitro Pharmacological Action of Amiodarone upon Nav1.5. | Joviano-Santos, JV., et al. 2021. Mol Pharmacol. 99: 448-459. PMID: 33824187
- Antiepileptic Drug Tiagabine Does Not Directly Target Key Cardiac Ion Channels Kv11.1, Nav1.5 and Cav1.2. | Kowalska, M., et al. 2021. Molecules. 26: PMID: 34207748
- Synthesis and In Vivo Antiarrhythmic Activity Evaluation of Novel Scutellarein Analogues as Voltage-Gated Nav1.5 and Cav1.2 Channels Blockers. | Yang, W., et al. 2023. Molecules. 28: PMID: 37959836
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Na+ CP type Vα Antibody (4G8:1G7) | sc-81631 | 200 µg/ml | $322.00 |