Na⁺ CP type IXα Antibody (5A11): sc-293298

Na+ CP type IXα Antibody (5A11) is a mouse monoclonal IgG2b kappa light chain antibody that detects the Na+ CP type IX alpha protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Na+ CP type IXα (5A11) antibody is available as a non-conjugated anti-Na+ CP type IX alpha antibody. The Na+ CP type IXα protein, also known as SCN9A, NENA, PN1, Nav1.7, or ETHA, is a crucial component of the voltage-gated sodium channel family, consisting of 1,988 amino acids and functioning as a multi-pass membrane protein. Na+ CP type IXα is primarily located in the dorsal root ganglion, smooth muscle cells, and both the central and peripheral nervous systems, where Na+ CP type IXα plays a vital role in mediating voltage-dependent sodium ion permeability across cellular membranes. Na+ CP type IXα forms a sodium-selective ion channel essential for the propagation of action potentials in excitable cells, allowing for rapid influx of sodium ions that leads to cell depolarization. Na+ CP type IXα is implicated in the inflammatory pain response, and mutations in the gene encoding Na+ CP type IXα can result in severe genetic pain disorders such as primary erythermalgia, congenital indifference to pain, and paroxysmal extreme pain disorder (PEPD). Anti-Na+ CP type IXα antibody (5A11) provides researchers with a valuable tool for studying the physiological and pathological roles of this critical protein in pain signaling and related conditions.

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Na⁺ CP type IXα Antibody (5A11) References:

1. Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia.  |  Yang, Y., et al. 2004. J Med Genet. 41: 171-4. PMID: 14985375
2. Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root ganglia.  |  Raymond, CK., et al. 2004. J Biol Chem. 279: 46234-41. PMID: 15302875
3. A Nav1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity.  |  Sheets, PL., et al. 2007. J Physiol. 581: 1019-31. PMID: 17430993
4. A stop codon mutation in SCN9A causes lack of pain sensation.  |  Ahmad, S., et al. 2007. Hum Mol Genet. 16: 2114-21. PMID: 17597096
5. Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders.  |  Drenth, JP. and Waxman, SG. 2007. J Clin Invest. 117: 3603-9. PMID: 18060017
6. Primary erythermalgia as a sodium channelopathy: screening for SCN9A mutations: exclusion of a causal role of SCN10A and SCN11A.  |  Drenth, JP., et al. 2008. Arch Dermatol. 144: 320-4. PMID: 18347287
7. Association analysis of SCN9A gene variants with borderline personality disorder.  |  Tadić, A., et al. 2008. J Psychiatr Res. 43: 155-63. PMID: 18439623
8. SLC20A2 Deficiency in Mice Leads to Elevated Phosphate Levels in Cerbrospinal Fluid and Glymphatic Pathway-Associated Arteriolar Calcification, and Recapitulates Human Idiopathic Basal Ganglia Calcification.  |  Wallingford, MC., et al. 2017. Brain Pathol. 27: 64-76. PMID: 26822507
9. Slc20a2-Deficient Mice Exhibit Multisystem Abnormalities and Impaired Spatial Learning Memory and Sensorimotor Gating but Normal Motor Coordination Abilities.  |  Ren, Y., et al. 2021. Front Genet. 12: 639935. PMID: 33889180
10. Antisense oligonucleotides enhance SLC20A2 expression and suppress brain calcification in a humanized mouse model.  |  Zhao, M., et al. 2024. Neuron. 112: 3278-3294.e7. PMID: 39121859
11. Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells.  |  Klugbauer, N., et al. 1995. EMBO J. 14: 1084-90. PMID: 7720699
12. A novel tetrodotoxin-sensitive, voltage-gated sodium channel expressed in rat and human dorsal root ganglia.  |  Sangameswaran, L., et al. 1997. J Biol Chem. 272: 14805-9. PMID: 9169448

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Na⁺ CP type IXα Antibody (5A11) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Na⁺ CP type IXα Antibody (5A11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Na⁺ CP type IXα Antibody (5A11) Specifications

Alternate Product Name: Na+ CP type IXα

Product Clone Name: 5A11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 269-339

Epitope Target: Na⁺ CP type IXα

Epitope Species: human

Product Reactivity/Detection: Na⁺ CP type IXα

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Na⁺ CP type IXα Antibody (5A11): N/A