N6-Carbobenzoxy-L-lysine N-Carboxyanhydride (CAS 1676-86-4)

N6-Carbobenzoxy-L-lysine N-Carboxyanhydride (N6-CBZ-L-Lys-NCA) is a critical reagent in the realm of organic synthesis and peptide chemistry. It facilitates the creation of diverse peptides, peptidomimetics, and other molecules. Its mild and selective nature sets it apart from other reagents like dicyclohexylcarbodiimide (DCC) and N-hydroxysuccinimide (NHS), making it useful in organic synthesis. Its application extends to the production of various cyclic, constrained, and macrocyclic peptides, as well as small molecules, polymers, and polypeptides. One of its standout features is its ability to establish a stable carbamate bond between the carboxylic acid group of the N6-Carbobenzoxy-L-lysine N-Carboxyanhydride and the carboxyanhydride group of the NCA. This bond is more steadfast than the amide bonds formed by other reagents, less susceptible to hydrolysis, and thus contributes to N6-Carbobenzoxy-L-lysine N-Carboxyanhydride being a more selective and milder reagent for peptide and peptidomimetic synthesis.