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(−)-N6-(2-Phenylisopropyl)adenosine (CAS 38594-96-6)

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Alternate Names:
R-(−)-PIA
Application:
(−)-N6-(2-Phenylisopropyl)adenosine is an Adenosine A1-R (A1 adenosine receptor)agonist
CAS Number:
38594-96-6
Purity:
≥98%
Molecular Weight:
385.42
Molecular Formula:
C19H23N5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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(−)-N6-(2-Phenylisopropyl)adenosine is a potent and selective agonist for the adenosine A1 receptor. It functions by binding to and activating the A1 receptor, leading to the inhibition of adenylyl cyclase activity and subsequent reduction in cAMP levels. (−)-N6-(2-Phenylisopropyl)Adenosine modulates neurotransmitter release, particularly inhibiting the release of excitatory neurotransmitters such as glutamate. By doing so, it plays a role in regulating synaptic transmission and neuronal excitability. (−)-N6-(2-Phenylisopropyl)adenosine may have neuroprotective effects, potentially through its ability to reduce excitotoxicity and oxidative stress. Its mechanism of action involves the modulation of ion channels and the regulation of intracellular signaling pathways, ultimately influencing neuronal function and synaptic plasticity. (−)-N6-(2-Phenylisopropyl)adenosine is useful in the studying the physiological and pathophysiological roles of adenosine receptors in the central nervous system.


(−)-N6-(2-Phenylisopropyl)adenosine (CAS 38594-96-6) References

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  5. Differential desensitization of A1 adenosine receptor-mediated inhibition of cardiac myocyte contractility and adenylate cyclase activity. Relation to the regulation of receptor affinity and density.  |  Liang, BT. and Donovan, LA. 1990. Circ Res. 67: 406-14. PMID: 2376079
  6. The ability of denbufylline to inhibit cyclic nucleotide phosphodiesterase and its affinity for adenosine receptors and the adenosine re-uptake site.  |  Nicholson, CD., et al. 1989. Br J Pharmacol. 97: 889-97. PMID: 2474352
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  11. Agonist-independent effect of an allosteric enhancer of the A1 adenosine receptor in CHO cells stably expressing the recombinant human A1 receptor.  |  Kollias-Baker, CA., et al. 1997. J Pharmacol Exp Ther. 281: 761-8. PMID: 9152383
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(−)-N6-(2-Phenylisopropyl)adenosine, 25 mg

sc-253169
25 mg
$133.00