Molecular structure of N2,N2,7-Trimethylguanosine, CAS Number: 40027-70-1
N2,N2,7-Trimethylguanosine (CAS 40027-70-1)
CAS Number:
40027-70-1
Purity:
≥95%
Molecular Weight:
326.33
Molecular Formula:
C13H20N5O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N2,N2,7-Trimethylguanosine functions as a ligand for specific proteins and enzymes. Notably, it has been identified to interact with acetylcholinesterase, an enzyme responsible for regulating acetylcholine levels in the brain. This binding capability presents an opportunity to modulate the enzyme′s activity and consequently impact the levels of acetylcholine in the brain. N2,N2,7-Trimethylguanosine is relatively stable, enabling it to be stored for extended durations without undergoing degradation.
N2,N2,7-Trimethylguanosine (CAS 40027-70-1) References
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- N2,N2,7-trimethylguanine, a new trimethylated guanine natural product from the New Zealand ascidian, Lissoclinum notti. | Pearce, AN., et al. 2001. Nat Prod Lett. 15: 237-41. PMID: 11833618
- Chromatographic, capillary electrophoretic and matrix-assisted laser desorption ionization time-of-flight mass spectrometry analysis of urinary modified nucleosides as tumor markers. | Liebich, HM., et al. 2005. J Chromatogr A. 1071: 271-5. PMID: 15865203
- MALDI-TOF MS analysis of urinary nucleosides. | Kammerer, B., et al. 2005. J Am Soc Mass Spectrom. 16: 940-7. PMID: 15907708
- A novel approach to solid phase chemical synthesis of oligonucleotide mRNA cap analogs. | Jemielity, J., et al. 2005. Nucleosides Nucleotides Nucleic Acids. 24: 601-5. PMID: 16247996
- Systematic identification of non-coding RNA 2,2,7-trimethylguanosine cap structures in Caenorhabditis elegans. | Jia, D., et al. 2007. BMC Mol Biol. 8: 86. PMID: 17903271
- Metabolic signature of breast cancer cell line MCF-7: profiling of modified nucleosides via LC-IT MS coupling. | Bullinger, D., et al. 2007. BMC Biochem. 8: 25. PMID: 18047657
- Identification of urinary modified nucleosides and ribosylated metabolites in humans via combined ESI-FTICR MS and ESI-IT MS analysis. | Bullinger, D., et al. 2008. J Am Soc Mass Spectrom. 19: 1500-13. PMID: 18657436
- 5'-Terminal chemical capping of spliced leader RNAs. | Piecyk, K., et al. 2012. Tetrahedron Lett. 53: 4843-4847. PMID: 23175583
- Synthesis of N2, N2, 7-trimethylguanosine cap derivatives. | Iwase, R., et al. 1989. Nucleic Acids Res. 17: 8979-89. PMID: 2587250
- Antibodies elicited by N2,N2-7-trimethylguanosine react with small nuclear RNAs and ribonucleoproteins. | Smith, JH. and Eliceiri, GL. 1983. J Biol Chem. 258: 4636-40. PMID: 6187738
- Sensitivity to UV radiation of small nuclear RNA synthesis in mammalian cells. | Eliceiri, GL. and Smith, JH. 1983. Mol Cell Biol. 3: 2151-5. PMID: 6197625
- Wheat embryo ribonucleates. XII. Formal characterization of terminal and penultimate nucleoside residues at the 5'-ends of 'capped' RNA from imbibing wheat embryos. | Haffner, MH., et al. 1978. Can J Biochem. 56: 729-33. PMID: 688062
- Fluorescence and absorption spectroscopic properties of RNA 5'-cap analogues derived from 7-methyl-, N2,7-dimethyl- and N2,N2,7-trimethyl-guanosines. | Wieczorek, Z., et al. 1995. J Photochem Photobiol B. 28: 57-63. PMID: 7791006
- U1 small nuclear RNA and spliceosomal introns in Euglena gracilis. | Breckenridge, DG., et al. 1999. Proc Natl Acad Sci U S A. 96: 852-6. PMID: 9927657
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N2,N2,7-Trimethylguanosine, 1 mg | sc-286465 | 1 mg | $480.00 | |||
N2,N2,7-Trimethylguanosine, 1.5 mg | sc-286465A | 1.5 mg | $590.00 |