N1,N11-Diethylnorspermine tetrahydrochloride (CAS 156886-85-0)
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N1,N11-Diethylnorspermine tetrahydrochloride (DENSPM) stands as a highly potent inducer of spermidine/spermine N1-acetyltransferase (SSAT), a key enzyme within the polyamine catabolic pathway, demonstrating an ability to enhance SSAT activity by an impressive range of 200-1000 fold. This remarkable induction capability positions N1,N11-Diethylnorspermine tetrahydrochloride as a tool in research focusing on the modulation of polyamine metabolism, offering a unique window into understanding the intricate balance and regulatory mechanisms governing cellular polyamine levels. By driving the acetylation process through SSAT activation, N1,N11-Diethylnorspermine tetrahydrochloride facilitates the degradation and export of polyamines from cells, thereby influencing polyamine homeostasis and impacting cellular functions related to polyamine dynamics. This mechanism of action underscores the utility of N1,N11-Diethylnorspermine tetrahydrochloride in scientific studies aimed at elucidating the role of polyamines in cellular physiology and pathophysiology, beyond its immediate effects on SSAT activity. Its application in research applications provides valuable insights into the potential modulation of polyamine metabolism, making it an essential tool for investigators exploring the complexities of cellular growth, proliferation, and differentiation processes governed by polyamine concentrations.
N1,N11-Diethylnorspermine tetrahydrochloride (CAS 156886-85-0) References
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- Combination of 5-fluorouracil and N1,N11-diethylnorspermine markedly activates spermidine/spermine N1-acetyltransferase expression, depletes polyamines, and synergistically induces apoptosis in colon carcinoma cells. | Choi, W., et al. 2005. J Biol Chem. 280: 3295-304. PMID: 15546879
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N1,N11-Diethylnorspermine tetrahydrochloride, 1 mg | sc-204114 | 1 mg | $145.00 | |||
N1,N11-Diethylnorspermine tetrahydrochloride, 5 mg | sc-204114A | 5 mg | $599.00 | |||
N1,N11-Diethylnorspermine tetrahydrochloride, 10 mg | sc-204114B | 10 mg | $1195.00 |