N-type Ca++ CP α1B Antibody (A-11): sc-271010
- N-type Ca++ CP α1B Antibody (A-11) is a mouse monoclonal IgG3 κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 1841-1995 mapping near the C-terminus of N-type Ca++ CP α1B of human origin
- recommended for detection of N-type calcium channel α1B of human origin by WB, IP, IF and ELISA
- m-IgG3 BP-HRP is the preferred secondary detection reagent for N-type Ca++ CP α1B Antibody (A-11) for WB applications. This reagent is now offered in a bundle with N-type Ca++ CP α1B Antibody (A-11) (see ordering information below).
QUICK LINKS
SEE ALSO...
N-type Ca++ CP α1B Antibody (A-11) is a mouse monoclonal IgG3 antibody that detects N-type Ca++ channel α1B in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). N-type Ca++ channels are predominantly located in presynaptic nerve terminals, where they play a pivotal role in neuronal excitation-secretion coupling, facilitating the release of neurotransmitters essential for synaptic transmission. The α1B subunit of these channels is crucial for conducting N-type calcium currents, which are necessary for initiating rapid synaptic transmission. Additionally, the α1B subunit interacts with key proteins involved in synaptic vesicle docking and fusion, including syntaxin, SNAP-25, and synaptotagmin, through specific interaction sites located in the intracellular loop II-III. This interaction is vital for the precise regulation of neurotransmitter release, underscoring the importance of N-type Ca++ channels in both neuronal communication and cardiovascular regulation through the autonomic nervous system. N-type Ca++ CP α1B (A-11) antibody is an invaluable tool for researchers studying these critical processes in human tissues.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
N-type Ca++ CP α1B Antibody (A-11) References:
- Use-dependent blockade of Cav2.2 voltage-gated calcium channels for neuropathic pain. | Winquist, RJ., et al. 2005. Biochem Pharmacol. 70: 489-99. PMID: 15950195
- Venom peptides as a rich source of cav2.2 channel blockers. | Sousa, SR., et al. 2013. Toxins (Basel). 5: 286-314. PMID: 23381143
- Tetraspanin-13 modulates voltage-gated CaV2.2 Ca2+ channels. | Mallmann, RT., et al. 2013. Sci Rep. 3: 1777. PMID: 23648579
- Challenging the catechism of therapeutics for chronic neuropathic pain: Targeting CaV2.2 interactions with CRMP2 peptides. | Feldman, P. and Khanna, R. 2013. Neurosci Lett. 557 Pt A: 27-36. PMID: 23831344
- Ankyrin-B regulates Cav2.1 and Cav2.2 channel expression and targeting. | Kline, CF., et al. 2014. J Biol Chem. 289: 5285-95. PMID: 24394417
- Mechanism of direct Cav2.2 channel block by the κ-opioid receptor agonist U50488H. | Berecki, G., et al. 2016. Neuropharmacology. 109: 49-58. PMID: 27245500
- Differential regulation of Cav2.2 channel exon 37 variants by alternatively spliced μ-opioid receptors. | Gandini, MA., et al. 2019. Mol Brain. 12: 98. PMID: 31775826
- Knockdown of microglial Cav2.2 N-type voltage-dependent Ca2+ channel ameliorates behavioral deficits in a mouse model of Parkinson's disease. | Saegusa, H., et al. 2020. FEBS Lett. 594: 2914-2922. PMID: 32484574
- Rhodojaponin VI indirectly targets Cav2.2 channels via N-ethylmaleimide-sensitive fusion protein to alleviate neuropathic pain. | Chen, K., et al. 2023. Acta Pharm Sin B. 13: 1326-1336. PMID: 36970201
- Schisandrin B from Schisandra chinensis alleviated pain via glycine receptors, Nav1.7 channels and Cav2.2 channels. | Zhao, M., et al. 2024. J Ethnopharmacol. 326: 117996. PMID: 38431110
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-type Ca++ CP α1B Antibody (A-11) | sc-271010 | 200 µg/ml | $322.00 | |||
N-type Ca++ CP α1B Antibody (A-11): m-IgG3 BP-HRP Bundle | sc-550397 | 200 µg Ab; 40 µg BP | $361.00 |