Molecular structure of N-Trifluoroacetyl-N-methyl-deacetylcolchicine
N-Trifluoroacetyl-N-methyl-deacetylcolchicine
Molecular Weight:
467.44
Molecular Formula:
C23H24F3NO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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An antimitotic agent that interrupts microtubles by binding to tubulin and preventing polymerization. Stimulates the intrinsic GTPase activity of tubulin. Apoptosis inducer in normal and tumor cell lines and activates the JNK/SAPK signaling.
N-Trifluoroacetyl-N-methyl-deacetylcolchicine References
- Tubulin structure and biochemistry. | Ludueña, RF., et al. 1992. Curr Opin Cell Biol. 4: 53-7. PMID: 1558754
- Apoptosis in rat hippocampal dentate gyrus after intraventricular colchicine. | Ceccatelli, S., et al. 1997. Neuroreport. 8: 3779-83. PMID: 9427370
- Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways. | Wang, TH., et al. 1998. J Biol Chem. 273: 4928-36. PMID: 9478937
- Role of the colchicine ring A and its methoxy groups in the binding to tubulin and microtubule inhibition. | Andreu, JM., et al. 1998. Biochemistry. 37: 8356-68. PMID: 9622487
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Trifluoroacetyl-N-methyl-deacetylcolchicine, 250 mg | sc-219254 | 250 mg | $300.00 |