Molecular structure of N-Trifluoroacetyl Deacetylcolchicine
N-Trifluoroacetyl Deacetylcolchicine
Molecular Weight:
453.41
Molecular Formula:
C22H22F3NO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
An antimitotic agent that interrupts microtubles by binding to tubulin and preventing polymerization. Stimulates the intrinsic GTPase activity of tubulin. Apoptosis inducer in normal and tumor cell lines and activates the JNK/SAPK signaling.
N-Trifluoroacetyl Deacetylcolchicine References
- Tubulin structure and biochemistry. | Ludueña, RF., et al. 1992. Curr Opin Cell Biol. 4: 53-7. PMID: 1558754
- Apoptosis in rat hippocampal dentate gyrus after intraventricular colchicine. | Ceccatelli, S., et al. 1997. Neuroreport. 8: 3779-83. PMID: 9427370
- Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways. | Wang, TH., et al. 1998. J Biol Chem. 273: 4928-36. PMID: 9478937
- Role of the colchicine ring A and its methoxy groups in the binding to tubulin and microtubule inhibition. | Andreu, JM., et al. 1998. Biochemistry. 37: 8356-68. PMID: 9622487
- Simple conversion of colchicine into demecolcine. | Capraro, Hans‐Georg and Arnold Brossi. 1979. Helvetica Chimica Acta. 62.4: 965-970.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Trifluoroacetyl Deacetylcolchicine, 50 mg | sc-358439 | 50 mg | $260.00 |