Molecular structure of N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide, CAS Number: 77377-52-7
N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide (CAS 77377-52-7)
Alternate Names:
MTBSTFA
CAS Number:
77377-52-7
Purity:
≥97%
Molecular Weight:
241.33
Molecular Formula:
C9H18F3NOSi
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide is a highly utilized silylation reagent with extensive applications in both organic synthesis and analytical chemistry. It plays a pivotal role in various tasks, including the derivatization of primary and secondary amines, peptides, and proteins, as well as the synthesis of diverse organic compounds. Furthermore, it contributes to the detection and quantification of volatile organic compounds (VOCs), making it useful in analytical chemistry.
N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide (CAS 77377-52-7) References
- Detection of low levels of flunitrazepam and its metabolites in blood and bloodstains. | Elian, AA. 1999. Forensic Sci Int. 101: 107-11. PMID: 10371042
- Analysis of poly-beta-hydroxybutyrate in environmental samples by GC-MS/MS. | Elhottová, D., et al. 2000. Fresenius J Anal Chem. 367: 157-64. PMID: 11225876
- Determination of acidic drugs in sewage water by gas chromatography-mass spectrometry as tert.-butyldimethylsilyl derivatives. | Rodríguez, I., et al. 2003. J Chromatogr A. 985: 265-74. PMID: 12580494
- Comprehensive chemical derivatization for gas chromatography-mass spectrometry-based multi-targeted profiling of the major phytohormones. | Birkemeyer, C., et al. 2003. J Chromatogr A. 993: 89-102. PMID: 12735441
- Suitability of N,O-bis(trimethylsilyl)trifluoroacetamide and N-(tert-butyldimethylsilyl)-N-methyltrifluoroacetamide as derivatization reagents for the determination of the estrogens estrone and 17alpha-ethinylestradiol by gas chromatography-mass spectrometry. | Shareef, A., et al. 2004. J Chromatogr A. 1026: 295-300. PMID: 14763757
- Optimization of silylation using N-methyl-N-(trimethylsilyl)-trifluoroacetamide, N,O-bis-(trimethylsilyl)-trifluoroacetamide and N-(tert-butyldimethylsilyl)-N-methyltrifluoroacetamide for the determination of the estrogens estrone and 17alpha-ethinylestradiol by gas chromatography-mass spectrometry. | Shareef, A., et al. 2006. J Chromatogr A. 1108: 121-8. PMID: 16445920
- Differential metabolomics using stable isotope labeling and two-dimensional gas chromatography with time-of-flight mass spectrometry. | Huang, X. and Regnier, FE. 2008. Anal Chem. 80: 107-14. PMID: 18052339
- Determination of basic degradation products of chemical warfare agents in water using hollow fibre-protected liquid-phase microextraction with in-situ derivatisation followed by gas chromatography-mass spectrometry. | Lee, HS., et al. 2008. J Chromatogr A. 1196-1197: 125-32. PMID: 18456273
- Dispersive liquid-liquid microextraction applied to the simultaneous derivatization and concentration of triclosan and methyltriclosan in water samples. | Montes, R., et al. 2009. J Chromatogr A. 1216: 205-10. PMID: 19084234
- Comparison of MTBSTFA and BSTFA in derivatization reactions of polar compounds prior to GC/MS analysis. | Schummer, C., et al. 2009. Talanta. 77: 1473-82. PMID: 19084667
- Investigation of Organic Acids in Saffron Stigmas (Crocus sativus L.) Extract by Derivatization Method and Determination by GC/MS. | Jarukas, L., et al. 2020. Molecules. 25: PMID: 32731562
- Influence of Calcium Perchlorate on the Search for Martian Organic Compounds with MTBSTFA/DMF Derivatization. | He, Y., et al. 2021. Astrobiology. 21: 1137-1156. PMID: 34534003
- MTBSTFA derivatization-LC-MS/MS approach for the quantitative analysis of endogenous nucleotides in human colorectal carcinoma cells. | Zhang, H., et al. 2022. J Pharm Anal. 12: 77-86. PMID: 35573880
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide, 5 g | sc-215485 | 5 g | $149.00 |