Date published: 2025-12-5

1-800-457-3801

SCBT Portrait Logo
Seach Input

N-Succinimidyl Iodoacetate (CAS 39028-27-8)

0.0(0)
Write a reviewAsk a question

Alternate Names:
N-Iodoacetoxysuccinimide; N-Hydroxysuccinimidyl Iodoacetate; N-Hydroxysuccinimide Iodoacetic Acid Ester
Application:
N-Succinimidyl Iodoacetate is an amine and sulfhydryl reactive crosslinker, 1.5 angstrom spacer arm
CAS Number:
39028-27-8
Molecular Weight:
283.02
Molecular Formula:
C6H6INO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

N-Succinimidyl Iodoacetate is a sulfhydryl and amino reactive, heterobifunctional protein crosslinking reagent. Spacer Arm: 1.5 Angstroms. N-Succinimidyl Iodoacetate belongs to the pyrrolidine family, characterized by a cyclic amine with a five-membered ring structure. This colorless, odorless, and non-volatile compound has been employed in research to explore the biochemical and physiological impacts of drugs and compounds. In vitro studies employ N-Succinimidyl Iodoacetate in laboratory experiments, such as cell cultures and enzyme assays, to discover the compound′s biochemical and physiological effects.


N-Succinimidyl Iodoacetate (CAS 39028-27-8) References

  1. Activation of soluble polysaccharides with 1-cyano-4-dimethylaminopyridinium tetrafluoroborate (CDAP) for use in protein-polysaccharide conjugate vaccines and immunological reagents. II. Selective crosslinking of proteins to CDAP-activated polysaccharides.  |  Shafer, DE., et al. 2000. Vaccine. 18: 1273-81. PMID: 10649629
  2. Differential conjugation of tat peptide to superparamagnetic nanoparticles and its effect on cellular uptake.  |  Zhao, M., et al. 2002. Bioconjug Chem. 13: 840-4. PMID: 12121140
  3. Targeting of RGD-modified proteins to tumor vasculature: a pharmacokinetic and cellular distribution study.  |  Schraa, AJ., et al. 2002. Int J Cancer. 102: 469-75. PMID: 12432548
  4. Regulatory interactions between the amino terminus of G-protein betagamma subunits and the catalytic domain of phospholipase Cbeta2.  |  Bonacci, TM., et al. 2005. J Biol Chem. 280: 10174-81. PMID: 15611108
  5. Deficiency in Cardiac Dystrophin Affects the Abundance of the $\alpha$ -/ $\beta$ -Dystroglycan Complex.  |  Lohan, J., et al. 2005. J Biomed Biotechnol. 2005: 28-36. PMID: 15689636
  6. Metabolic biotinylation of cell surface receptors for in vivo imaging.  |  Tannous, BA., et al. 2006. Nat Methods. 3: 391-6. PMID: 16628210
  7. A novel approach to identify proteins modified by nitric oxide: the HIS-TAG switch method.  |  Camerini, S., et al. 2007. J Proteome Res. 6: 3224-31. PMID: 17629318
  8. A multimodal targeting nanoparticle for selectively labeling T cells.  |  Gunn, J., et al. 2008. Small. 4: 712-5. PMID: 18528851
  9. Protease-triggered unveiling of bioactive nanoparticles.  |  Harris, TJ., et al. 2008. Small. 4: 1307-12. PMID: 18690639
  10. Multistep DNA-templated reactions for the synthesis of functional sequence controlled oligomers.  |  McKee, ML., et al. 2010. Angew Chem Int Ed Engl. 49: 7948-51. PMID: 20836102
  11. The use of the fusion protein RGD-HSA-TIMP2 as a tumor targeting imaging probe for SPECT and PET.  |  Choi, N., et al. 2011. Biomaterials. 32: 7151-8. PMID: 21719102
  12. Simultaneous Enrichment of Cysteine-containing Peptides and Phosphopeptides Using a Cysteine-specific Phosphonate Adaptable Tag (CysPAT) in Combination with titanium dioxide (TiO2) Chromatography.  |  Huang, H., et al. 2016. Mol Cell Proteomics. 15: 3282-3296. PMID: 27281782
  13. Simultaneous Binding of Hybrid Molecules Constructed with Dual DNA-Binding Components to a G-Quadruplex and Its Proximal Duplex.  |  Asamitsu, S., et al. 2018. Chemistry. 24: 4428-4435. PMID: 29380465

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

N-Succinimidyl Iodoacetate, 100 mg

sc-212279
100 mg
$239.00