Molecular structure of N-Stearoyl-glycine, CAS Number: 6333-54-6
N-Stearoyl-glycine (CAS 6333-54-6)
Alternate Names:
2-(octadecanoylamino)acetic acid
Application:
N-Stearoyl-glycine is used in the study of bioactive N-acyl amides
CAS Number:
6333-54-6
Molecular Weight:
341.53
Molecular Formula:
C20H39NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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N-Stearoyl-glycine has been used in the study of bioactive N-acyl amides, a novel family of putative endogenous signaling lipids with multiple effects on pain, inflammation, and other biological systems. The effect of N-Stearoyl-glycine on primary sensory neurons has been studied, and single cell calcium imaging revealed a significant level of calcium influx, but still markedly lower than N-palmitoyl glycine. Recent studies have shown endogenous levels of N-Stearoyl-glycine are found in skin. N-Acyl glycines can be efficiently degraded by FAAH. FAAH is a microsomal enzyme involved in the hydrolysis of several bioactive amides and esters and can regulate in vivo levels of N-stearoyl glycine.
N-Stearoyl-glycine (CAS 6333-54-6) References
- N-palmitoyl glycine, a novel endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neurons. | Rimmerman, N., et al. 2008. Mol Pharmacol. 74: 213-24. PMID: 18424551
- Targeted lipidomics approach for endogenous N-acyl amino acids in rat brain tissue. | Tan, B., et al. 2009. J Chromatogr B Analyt Technol Biomed Life Sci. 877: 2890-4. PMID: 19168403
- Novel endogenous N-acyl glycines identification and characterization. | Bradshaw, HB., et al. 2009. Vitam Horm. 81: 191-205. PMID: 19647113
- Identification of glycine N-acyltransferase-like 2 (GLYATL2) as a transferase that produces N-acyl glycines in humans. | Waluk, DP., et al. 2010. FASEB J. 24: 2795-803. PMID: 20305126
- N-Acyl amino acids and their impact on biological processes. | Hanuš, L., et al. 2014. Biofactors. 40: 381-8. PMID: 24753374
- A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase. | Carey, LM., et al. 2016. Mol Pain. 12: PMID: 27178246
- Resveratrol protects from lipopolysaccharide-induced inflammation in the uterus and prevents experimental preterm birth. | Bariani, MV., et al. 2017. Mol Hum Reprod. 23: 571-581. PMID: 28810692
- Environmental Toxin Acrolein Alters Levels of Endogenous Lipids, Including TRP Agonists: A Potential Mechanism for Headache Driven by TRPA1 Activation. | Leishman, E., et al. 2017. Neurobiol Pain. 1: 28-36. PMID: 29430557
- Bioactive Lipids in Cancer, Inflammation and Related Diseases : Acute and Chronic Mild Traumatic Brain Injury Differentially Changes Levels of Bioactive Lipids in the CNS Associated with Headache. | Leishman, E., et al. 2019. Adv Exp Med Biol. 1161: 193-217. PMID: 31562631
- A Combined Metabolomic and Metagenomic Approach to Discriminate Raw Milk for the Production of Hard Cheese. | Bellassi, P., et al. 2021. Foods. 10: PMID: 33419189
- [Chronic treatment with tween-80 (5%) or n-stearoyl glycine on the antimobility effects of imipramine in the forced swimming test in mice]. | Vamvakidès, A. 1996. Boll Chim Farm. 135: 603-4. PMID: 9081294
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Stearoyl-glycine, 100 mg | sc-344958 | 100 mg | $560.00 |