N-(p-Nitrophenethyl)spiperone (CAS 136247-18-2)
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N-(p-Nitrophenethyl)spiperone is an analogue of Spiperone. Spiperone (sc-204293) is an 5-HT2A serotonin and selective D2-like dopamine receptor antagonist (Ki values are 0.06, 0.6, 0.08, ~ 350, ~ 3500 nM for D2, D3, D4, D1 and D5 receptors respectively). Although the well known role of Spiperone in research studies indicates it acts as an antagonist of either 5-HT2 or D2 receptors, Spiperone has also been reported to act through a protein tyrosine kinase-coupled phospholipase C-dependent pathway. Spiperone was observed to act independent of either 5-HT2 or D2 receptors as reported In a study investigating the role of Spiperone and Ca2+ activated Cl- (CaCC) in human cystic fibrosis (CF) airway epithelial cell monolayers in vitro.
N-(p-Nitrophenethyl)spiperone (CAS 136247-18-2) References
- A novel role of protein tyrosine kinase2 in mediating chloride secretion in human airway epithelial cells. | Liang, L., et al. 2011. PLoS One. 6: e21991. PMID: 21765932
- International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). | Hoyer, D., et al. 1994. Pharmacol Rev. 46: 157-203. PMID: 7938165
- Dopamine receptor pharmacology. | Seeman, P. and Van Tol, HH. 1994. Trends Pharmacol Sci. 15: 264-70. PMID: 7940991
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-(p-Nitrophenethyl)spiperone, 5 mg | sc-212019 | 5 mg | $380.00 |