N-(p-Amylcinnamoyl) anthranilic Acid (ACA) (CAS 110683-10-8)
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N-(p-Amylcinnamoyl) anthranilic Acid (ACA), a cell permeable inhibitor of PLA2, has been reported to inhibit alpha-ketoisocaproic acid and glyceraldehyde-induced insulin secretion, as well as glucose-induced insulin secretion. Additionally, by inhibiting PLA2, N-(p-Amylcinnamoyl) anthranilic Acid (ACA) consequentially suppresses glucose-induced arachidonic acid formation in cells. Furthermore, research has shown N-(p-Amylcinnamoyl) anthranilic Acid (ACA) to modulate the activity of different transient receptor potential channels. In particular, N-(p-Amylcinnamoyl) anthranilic Acid (ACA)′s blocking ability of diacylglycerol-activated TRP channels is of special interest since it offers the opportunity to interfere with receptor-induced Ca2+-dependent signaling processes in vascular smooth muscle cells and platelets. N-(p-Amylcinnamoyl) anthranilic Acid (ACA) acid, is a synthetic compound categorized as a cinnamic acid derivative. Its physical form is a white, crystalline solid that cannot dissolve in water but can dissolve in organic solvents.
N-(p-Amylcinnamoyl) anthranilic Acid (ACA) (CAS 110683-10-8) References
- Regulation of lung surfactant secretion by phospholipase A2. | Liu, L. 1999. J Cell Biochem. 72: 103-10. PMID: 10025671
- Inhibition of phospholipase A2 and insulin secretion in pancreatic islets. | Konrad, RJ., et al. 1992. Biochim Biophys Acta. 1135: 215-20. PMID: 1616940
- Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid. | Kraft, R., et al. 2006. Br J Pharmacol. 148: 264-73. PMID: 16604090
- N-(p-amylcinnamoyl)anthranilic acid (ACA): a phospholipase A(2) inhibitor and TRP channel blocker. | Harteneck, C., et al. 2007. Cardiovasc Drug Rev. 25: 61-75. PMID: 17445088
- Inhibition of the Na+/dicarboxylate cotransporter by anthranilic acid derivatives. | Pajor, AM. and Randolph, KM. 2007. Mol Pharmacol. 72: 1330-6. PMID: 17715401
- H2O2-induced Ca2+ influx and its inhibition by N-(p-amylcinnamoyl) anthranilic acid in the beta-cells: involvement of TRPM2 channels. | Bari, MR., et al. 2009. J Cell Mol Med. 13: 3260-7. PMID: 19382906
- Inhibition of the calcium-activated chloride current in cardiac ventricular myocytes by N-(p-amylcinnamoyl)anthranilic acid (ACA). | Gwanyanya, A., et al. 2010. Biochem Biophys Res Commun. 402: 531-6. PMID: 20971070
- Protective effect of N-(p-amylcinnamoyl) anthranilic acid, phospholipase A2 enzyme inhibitor, and transient receptor potential melastatin-2 channel blocker against renal ischemia-reperfusion injury. | Çakır, M., et al. 2019. J Cell Biochem. 120: 3822-3832. PMID: 30259992
- N-(p-amylcinnamoyl) anthranilic acid attenuates remedial effects of memantine on memory deficits following intracerebroventricular streptozotocin administration in rats. | Göl, M., et al. 2019. Arch Ital Biol. 157: 24-36. PMID: 31111954
- TRPM2 Promotes Atherosclerotic Progression in a Mouse Model of Atherosclerosis. | Zhang, Y., et al. 2022. Cells. 11: PMID: 35563730
- Arginine vasopressin-stimulated insulin secretion and elevation of intracellular Ca++ concentration in rat insulinoma cells: influences of a phospholipase C inhibitor 1-[6-[[17 beta-methoxyestra-1,3,5(10)-trien- 17-yl]amino]hexyl]-1H-pyrrole-2,5-dione (U-73122) and a phospholipase A2 inhibitor N-(p-amylcinnamoyl)anthranilic acid. | Chen, TH., et al. 1994. J Pharmacol Exp Ther. 270: 900-4. PMID: 7932202
- Inhibition of glucose-induced insulin secretion by the diacylglycerol lipase inhibitor RHC 80267 and the phospholipase A2 inhibitor ACA through stimulation of K+ permeability without diminution by exogenous arachidonic acid. | Thams, P. and Capito, K. 1997. Biochem Pharmacol. 53: 1077-86. PMID: 9175712
- Ca2+-independent phospholipase A2 contributes to the insulinotropic action of cholecystokinin-8 in rat islets: dissociation from the mechanism of carbachol. | Simonsson, E., et al. 1998. Diabetes. 47: 1436-43. PMID: 9726232
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-(p-Amylcinnamoyl) anthranilic Acid (ACA), 50 mg | sc-200734 | 50 mg | $97.00 | |||
N-(p-Amylcinnamoyl) anthranilic Acid (ACA), 250 mg | sc-200734A | 250 mg | $307.00 |