N-(p-Aminophenethyl)spiperone (CAS 93801-18-4)
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N-(p-Aminophenethyl)spiperone is an analogue of Spiperone (sc-204293). Spiperone (sc-204293) is an 5-HT2A serotonin and selective D2-like dopamine receptor antagonist (Ki values are 0.06, 0.6, 0.08, ~ 350, ~ 3500 nM for D2, D3, D4, D1 and D5 receptors respectively). Although the well known role of Spiperone in research studies indicates it acts as an antagonist of either 5-HT2 or D2 receptors, Spiperone has also been reported to act through a protein tyrosine kinase-coupled phospholipase C-dependent pathway. Spiperone was observed to act independent of either 5-HT2 or D2 receptors as reported In a study investigating the role of Spiperone and Ca2+ activated Cl- channels (CaCC) in human cystic fibrosis (CF) airway epithelial cell monolayers in vitro.
N-(p-Aminophenethyl)spiperone (CAS 93801-18-4) References
- Time-resolved FRET between GPCR ligands reveals oligomers in native tissues. | Albizu, L., et al. 2010. Nat Chem Biol. 6: 587-94. PMID: 20622858
- A novel role of protein tyrosine kinase2 in mediating chloride secretion in human airway epithelial cells. | Liang, L., et al. 2011. PLoS One. 6: e21991. PMID: 21765932
- BRET and Time-resolved FRET strategy to study GPCR oligomerization: from cell lines toward native tissues. | Cottet, M., et al. 2012. Front Endocrinol (Lausanne). 3: 92. PMID: 22837753
- Direct visualization and cellular localization of D1 and D2 dopamine receptors in rat forebrain by use of fluorescent ligands. | Ariano, MA., et al. 1989. Proc Natl Acad Sci U S A. 86: 8570-4. PMID: 2479025
- Untangling dopamine-adenosine receptor-receptor assembly in experimental parkinsonism in rats. | Fernández-Dueñas, V., et al. 2015. Dis Model Mech. 8: 57-63. PMID: 25398851
- Design of a True Bivalent Ligand with Picomolar Binding Affinity for a G Protein-Coupled Receptor Homodimer. | Pulido, D., et al. 2018. J Med Chem. 61: 9335-9346. PMID: 30257092
- Design of bivalent ligands targeting putative GPCR dimers. | Huang, B., et al. 2021. Drug Discov Today. 26: 189-199. PMID: 33075471
- Fluorescent ligands for dopamine D2/D3 receptors. | Allikalt, A., et al. 2020. Sci Rep. 10: 21842. PMID: 33318558
- International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). | Hoyer, D., et al. 1994. Pharmacol Rev. 46: 157-203. PMID: 7938165
- Dopamine receptor pharmacology. | Seeman, P. and Van Tol, HH. 1994. Trends Pharmacol Sci. 15: 264-70. PMID: 7940991
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-(p-Aminophenethyl)spiperone, 1 mg | sc-207924 | 1 mg | $330.00 |