Molecular structure of N-Oxalyl-L-alanine, CAS Number: 5302-46-5
N-Oxalyl-L-alanine (CAS 5302-46-5)
Alternate Names:
NOLA; N-Oxalyl-2S-alanine; NOxSA
Application:
N-Oxalyl-L-alanine is a competitive HF PHD inhibitor that is cell permemeable in vitro
CAS Number:
5302-46-5
Purity:
≥98%
Molecular Weight:
161.13
Molecular Formula:
C5H7NO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
N-Oxalyl-L-alanine is a compound that functions as a potent inhibitor of serine proteases. It acts by irreversibly binding to the active site of the enzyme, forming a covalent bond with the serine residue. This interaction effectively blocks the catalytic activity of the protease, preventing it from cleaving peptide bonds in its substrate molecules. As a result, N-Oxalyl-L-alanine disrupts the normal function of serine proteases, thereby interfering with various cellular processes that rely on their activity.
N-Oxalyl-L-alanine (CAS 5302-46-5) References
- Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. | Jaakkola, P., et al. 2001. Science. 292: 468-72. PMID: 11292861
- Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha. | Elkins, JM., et al. 2003. J Biol Chem. 278: 1802-6. PMID: 12446723
- A fluorescence-based assay for 2-oxoglutarate-dependent oxygenases. | McNeill, LA., et al. 2005. Anal Biochem. 336: 125-31. PMID: 15582567
- The broad spectrum 2-oxoglutarate oxygenase inhibitor N-oxalylglycine is present in rhubarb and spinach leaves. | Al-Qahtani, K., et al. 2015. Phytochemistry. 117: 456-461. PMID: 26196940
Inhibitor of:
Enzyme, and HIF PHD.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Oxalyl-L-alanine, 10 mg | sc-205959 | 10 mg | $42.00 | |||
N-Oxalyl-L-alanine, 50 mg | sc-205959A | 50 mg | $125.00 |