Molecular structure of N-ω-Propyl-L-Arginine, CAS Number: 137361-05-8
N-ω-Propyl-L-Arginine (CAS 137361-05-8)
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Alternate Names:
N5-[imino(propylamino)methyl]-L-ornithine
Application:
N-ω-Propyl-L-Arginine is a selective inhibitor of NOS1
CAS Number:
137361-05-8
Purity:
>98%
Molecular Weight:
216.28
Molecular Formula:
C9H20N4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N-ω-Propyl-L-Arginine is a potent and selective inhibitor of NOS1 (nNOS). N-ω-Propyl-L-Arginine is a competitive inhibitor of bovine NOS1 having a Ki value of 57 nM. The Ki values for NOS3 (bovine) and NOS2 (murine) are 8.5 and 180 muM, respectively. N-ω-Propyl-L-Arginine therefore exhibits 3,000-fold and 150-fold selectivity for the NOS1 (neuronal) isoform versus the NOS2 (inducible) murine and NOS3 (endothelial) bovine isoforms of NOS, respectively.
N-ω-Propyl-L-Arginine (CAS 137361-05-8) References
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- Cellular and enzymatic studies of N(omega)-propyl-l-arginine and S-ethyl-N-[4-(trifluoromethyl)phenyl]isothiourea as reversible, slowly dissociating inhibitors selective for the neuronal nitric oxide synthase isoform. | Cooper, GR., et al. 2000. Arch Biochem Biophys. 375: 183-94. PMID: 10683266
- The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney. | Kakoki, M., et al. 2001. Am J Physiol Regul Integr Comp Physiol. 281: R91-7. PMID: 11404282
- Endothelial nitric oxide modulates perivascular sensory neurotransmission in the rat isolated mesenteric arterial bed. | Ralevic, V. 2002. Br J Pharmacol. 137: 19-28. PMID: 12183327
- The effects of N(omega)-propyl-L-arginine on reperfusion injury of skeletal muscle. | Gowda, C., et al. 2004. Nitric Oxide. 11: 17-24. PMID: 15350553
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- Selective loss of basal but not receptor-stimulated relaxation by endothelial nitric oxide synthase after isolation of the mouse aorta. | van Langen, J., et al. 2012. Eur J Pharmacol. 696: 111-9. PMID: 23022329
- Nitric oxide synthase inhibitors prevent the growth-inhibiting effects of quinpirole. | Nickla, DL., et al. 2013. Optom Vis Sci. 90: 1167-75. PMID: 24061155
- The Presence of the Neuronal Nitric Oxide Synthase Isoform in the Intervertebral Disk. | Castania, V., et al. 2017. Neurotox Res. 31: 148-161. PMID: 27761804
- Nitric Oxide Synthase inhibition counteracts the stress-induced DNA methyltransferase 3b expression in the hippocampus of rats. | de Sousa Maciel, I., et al. 2022. Eur J Neurosci. 55: 2421-2434. PMID: 33170977
- S-Nitrosylation of Histone Deacetylase 2 by Neuronal Nitric Oxide Synthase as a Mechanism of Diastolic Dysfunction. | Yoon, S., et al. 2021. Circulation. 143: 1912-1925. PMID: 33715387
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- Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine. | Zhang, HQ., et al. 1997. J Med Chem. 40: 3869-70. PMID: 9397167
Inhibitor of:
NOS1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-ω-Propyl-L-Arginine, 5 mg | sc-224171 | 5 mg | $72.00 | |||
N-ω-Propyl-L-Arginine, 10 mg | sc-224171A | 10 mg | $193.00 |