Molecular structure of N-Oleoyldopamine (OLDA), CAS Number: 105955-11-1
N-Oleoyldopamine (OLDA) (CAS 105955-11-1)
Alternate Names:
N-[2-(3,4-dihydroxyphenyl)ethyl]-9Z-octadecenamide; OLDA
Application:
N-Oleoyldopamine (OLDA) is a VR activator and 5-LO inhibitor
CAS Number:
105955-11-1
Molecular Weight:
417.6
Molecular Formula:
C26H43NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
N-Oleoyldopamine (OLDA) is an endogenous lipid compund in the mammalian brain. It has been found to be a VR1 (TRPV1) activator and potent 5-LO inhibitor. Activation of the VR1 receptor induces glutamate release and paraventricular nucleus postsynaptic firing. OLDA has been reported to induce the influx of calcium in VR1-transfected human embryonic kindey 293 cells. It has also been reported to induce the accumulation of cAMP in GPR119-transfected cells. OLDA has been also been observed to stimulate the release of insulin in HIT-T15 cells that endogenously express GPR119.
N-Oleoyldopamine (OLDA) (CAS 105955-11-1) References
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- VR1 receptor activation induces glutamate release and postsynaptic firing in the paraventricular nucleus. | Li, DP., et al. 2004. J Neurophysiol. 92: 1807-16. PMID: 15115794
- Targeted lipidomics: fatty acid amides and pain modulation. | Walker, JM., et al. 2005. Prostaglandins Other Lipid Mediat. 77: 35-45. PMID: 16099389
- Antioxidant and neuroprotective properties of N-arachidonoyldopamine. | Bobrov, MY., et al. 2008. Neurosci Lett. 431: 6-11. PMID: 18069125
- Antinociceptive desensitizing actions of TRPV1 receptor agonists capsaicin, resiniferatoxin and N-oleoyldopamine as measured by determination of the noxious heat and cold thresholds in the rat. | Bölcskei, K., et al. 2010. Eur J Pain. 14: 480-6. PMID: 19800272
- N-oleoyldopamine enhances glucose homeostasis through the activation of GPR119. | Chu, ZL., et al. 2010. Mol Endocrinol. 24: 161-70. PMID: 19901198
- A molecular screening approach to identify and characterize inhibitors of glioblastoma stem cells. | Visnyei, K., et al. 2011. Mol Cancer Ther. 10: 1818-28. PMID: 21859839
- A sensitive and accurate quantitative method to determine N-arachidonoyldopamine and N-oleoyldopamine in the mouse striatum using column-switching LC-MS-MS: use of a surrogate matrix to quantify endogenous compounds. | Ji, D., et al. 2014. Anal Bioanal Chem. 406: 4491-9. PMID: 24817351
- N-oleoyldopamine modulates activity of midbrain dopaminergic neurons through multiple mechanisms. | Sergeeva, OA., et al. 2017. Neuropharmacology. 119: 111-122. PMID: 28400256
- Bidirectional GPR119 Agonism Requires Peptide YY and Glucose for Activity in Mouse and Human Colon Mucosa. | Tough, IR., et al. 2018. Endocrinology. 159: 1704-1717. PMID: 29471473
- Mechanisms of N-oleoyldopamine activation of central histaminergic neurons. | De Luca, R., et al. 2018. Neuropharmacology. 143: 327-338. PMID: 30219501
- Hypersensitivity Induced by Intrathecal Bradykinin Administration Is Enhanced by N-oleoyldopamine (OLDA) and Prevented by TRPV1 Antagonist. | Uchytilova, E., et al. 2021. Int J Mol Sci. 22: PMID: 33918267
- N-Oleoyldopamine promotes the differentiation of mouse trophoblast stem cells into parietal trophoblast giant cells. | Nishitani, K., et al. 2022. Biochem Biophys Res Commun. 636: 205-212. PMID: 36335871
Inhibitor of:
5-LO.Activator of:
VR1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Oleoyldopamine (OLDA), 5 mg | sc-201456 | 5 mg | $77.00 | |||
N-Oleoyldopamine (OLDA), 25 mg | sc-201456A | 25 mg | $374.00 |