Molecular structure of N,N′-Octamethylenebis(2,2-dichloroacetamide), CAS Number: 1477-57-2
N,N′-Octamethylenebis(2,2-dichloroacetamide) (CAS 1477-57-2)
See product citations (7)
Alternate Names:
N,N′-Bis(dichloroacetyl)-1,8-octamethylenediamine; Bis-Diamine; Win 18446
Application:
N,N′-Octamethylenebis(2,2-dichloroacetamide) is an inhibitor of aldehyde dehydrogenase, ALDH1A2
CAS Number:
1477-57-2
Purity:
≥97%
Molecular Weight:
366.11
Molecular Formula:
C12H20Cl4N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N,N′-Octamethylenebis(2,2-dichloroacetamide) also called Fertilysin, is an inhibitor of aldehyde dehydrogenase, ALDH1A2. It is a small, naturally occurring peptide that may act to have a wide range of biological activities, including the promotion of fertility. It is believed to work by increasing the production of certain hormones, such as luteinizing hormone, which is responsible for the production of eggs in women, and follicle-stimulating hormone, which is responsible for the production of sperm in men. N,N′-Octamethylenebis(2,2-dichloroacetamide) may also act as a signaling molecule, stimulating the growth and maturation of embryos. Additionally, it may act to increase the production of certain proteins, such as follistatin, which is involved in the regulation of the menstrual cycle.
N,N′-Octamethylenebis(2,2-dichloroacetamide) (CAS 1477-57-2) References
- Efficacy, safety and reversibility of bisdiamine as a male contraceptive in cats. | Munson, L., et al. 2004. Theriogenology. 62: 81-92. PMID: 15159103
- Morphological differences in cardiovascular anomalies induced by bis-diamine between Sprague-Dawley and Wistar rats. | Fujino, H., et al. 2005. Congenit Anom (Kyoto). 45: 52-8. PMID: 15904432
- Teratogenic effects of bis-diamine on the developing cardiac conduction system. | Kise, K., et al. 2005. Birth Defects Res A Clin Mol Teratol. 73: 547-54. PMID: 15965974
- Hypoplasia of the lung and heart in fetal rats with diaphragmatic hernia. | Momma, K., et al. 1992. Fetal Diagn Ther. 7: 46-52. PMID: 1610503
- Fetal cardiovascular morphology of truncus arteriosus with or without truncal valve insufficiency in the rat. | Momma, K., et al. 1991. Circulation. 83: 2094-100. PMID: 1828193
- Inhibition of retinoic acid biosynthesis by the bisdichloroacetyldiamine WIN 18,446 markedly suppresses spermatogenesis and alters retinoid metabolism in mice. | Paik, J., et al. 2014. J Biol Chem. 289: 15104-17. PMID: 24711451
- Effects of exposing rat embryos in utero to physical or chemical teratogens are expressed later as enhanced induction of heat-shock proteins when embryonic hearts are cultured in vitro. | Higo, H., et al. 1988. Teratog Carcinog Mutagen. 8: 315-28. PMID: 2905543
- Isolating mitotic and meiotic germ cells from male mice by developmental synchronization, staging, and sorting. | Romer, KA., et al. 2018. Dev Biol. 443: 19-34. PMID: 30149006
- Design, synthesis, and ex vivo evaluation of a selective inhibitor for retinaldehyde dehydrogenase enzymes. | Harper, AR., et al. 2018. Bioorg Med Chem. 26: 5766-5779. PMID: 30409702
- The proportion of alveolar type 1 cells decreases in murine hypoplastic congenital diaphragmatic hernia lungs. | Nguyen, TM., et al. 2019. PLoS One. 14: e0214793. PMID: 30995255
- Developmental toxicity of N,N1-bis(dichloroacetyl)-1,8-octamethylene diamine: effects of in utero exposure on the postnatal murine immune system. | Porter, JF. and Schmidt, RR. 1986. Biol Neonate. 50: 221-30. PMID: 3778985
- Assessment of developmental toxicity potential of chemicals by quantitative structure-toxicity relationship models. | Gombar, VK., et al. 1995. Chemosphere. 31: 2499-510. PMID: 7670862
- Fetal in situ cardiovascular and pulmonary morphology of vascular ring due to left aortic arch and right ductus arteriosus in rats. | Momma, K. and Ando, M. 1995. Fetal Diagn Ther. 10: 41-7. PMID: 7710679
- Fetal cardiovascular morphology of interrupted aortic arch type B in rats. | Momma, K. and Ando, M. 1994. Fetal Diagn Ther. 9: 44-52. PMID: 8142052
Inhibitor of:
ALDH1A2, and CYP26A1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N,N′-Octamethylenebis(2,2-dichloroacetamide), 250 mg | sc-295819 | 250 mg | $180.00 | |||
N,N′-Octamethylenebis(2,2-dichloroacetamide), 1 g | sc-295819A | 1 g | $374.00 |