Date published: 2026-5-17

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N,N′-Disuccinimidyl carbonate (CAS 74124-79-1)

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Alternate Names:
bis(2,5-dioxopyrrolidin-1-yl) carbonate
Application:
N,N′-Disuccinimidyl carbonate is a reagent for the preparation of N-succinimidyl esters
CAS Number:
74124-79-1
Purity:
≥98%
Molecular Weight:
256.17
Molecular Formula:
C9H8N2O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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N,N′-Disuccinimidyl carbonate is an useful reagent for the synthesis of carbamates. This is used to prepare a heterobifucntional, cleavable linker-SVEC-(succinimide vinylsufonylethyl carbonate)-for thiol modified-DNA. It is used as a reagent for the preparation of N-succinimidyl esters of N-protected amino acids, activated carbonate, synthesis of urea, carbamates and coupling of ligands to proteins


N,N′-Disuccinimidyl carbonate (CAS 74124-79-1) References

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  7. Efficient magnetic recycling of covalently attached enzymes on carbon-coated metallic nanomagnets.  |  Zlateski, V., et al. 2014. Bioconjug Chem. 25: 677-84. PMID: 24673490
  8. Immunochemical rapid determination of quinoxyfen, a priority hazardous pollutant.  |  Duncan, H., et al. 2018. Chemosphere. 211: 302-307. PMID: 30077110
  9. N,N'-Disuccinimidyl Carbonate: A Useful Reagent for Alkoxycarbonylation of Amines.  |  Ghosh, AK., et al. 1992. Tetrahedron Lett. 33: 2781-2784. PMID: 30310243
  10. Novel Convenient Approach to the Solid-Phase Synthesis of Oligonucleotide Conjugates.  |  Meschaninova, MI., et al. 2019. Molecules. 24: PMID: 31771111
  11. Bilayer Cylindrical Conduit Consisting of Electrospun Polycaprolactone Nanofibers and DSC Cross-Linked Sodium Alginate Hydrogel to Bridge Peripheral Nerve Gaps.  |  Askarzadeh, N., et al. 2020. Macromol Biosci. 20: e2000149. PMID: 32627956
  12. Solubility of N, N'-Disuccinimidyl Carbonate and its relevance to polysaccharide functionalization.  |  Li, T. and Vanderah, D. 2021. Anal Biochem. 626: 114250. PMID: 33991484
  13. A simple procedure for enzyme labelling of progesterone derivatives: application of active esters formed using N,N'-disuccinimidyl carbonate.  |  Sauer, MJ. and Morris, BA. 1987. J Steroid Biochem. 26: 165-7. PMID: 3546945
  14. Covalently functionalized poly(etheretherketone) implants with osteogenic growth peptide (OGP) to improve osteogenesis activity.  |  Yakufu, M., et al. 2020. RSC Adv. 10: 9777-9785. PMID: 35498607
  15. Direct injection assay of drug enantiomers in serum on ovomucoid-bonded silica materials by liquid chromatography.  |  Haginaka, J., et al. 1993. J Chromatogr. 620: 199-204. PMID: 8300786

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

N,N′-Disuccinimidyl carbonate, 5 g

sc-253161
5 g
$95.00