N,N′-Carbonyldiimidazole (CAS 530-62-1)
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N,N′-Carbonyldiimidazole is a reagent utilized in organic synthesis, particularly for the activation of carboxylic acids to form amides, esters, and anhydrides. It is used for its efficiency in facilitating the formation of peptide bonds, which is a central reaction in the synthesis of polypeptides and proteins in the laboratory. Some employ N,N′-Carbonyldiimidazole in the preparation of various acylated compounds, taking advantage of its ability to act as a coupling agent that minimizes the formation of side products. This reactivity is also exploited in the synthesis of heterocycles, where it is used to introduce carbonyl groups into cyclic frameworks. Within material science, it is studied for its role in modifying the surface chemistry of polymers, where it can be used to attach bioactive molecules or other functional groups to polymer backbones.
N,N′-Carbonyldiimidazole (CAS 530-62-1) References
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- Corn starch ferulates with antioxidant properties prepared by N,N'-carbonyldiimidazole-mediated grafting procedure. | Wen, Y., et al. 2016. Food Chem. 208: 1-9. PMID: 27132817
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- Unsaturated Polyester Resin Nanocomposites Containing ZnO Modified with Oleic Acid Activated by N,N'-Carbonyldiimidazole. | Chen, H., et al. 2018. Polymers (Basel). 10: PMID: 30966397
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- Derivatization and determination of residual N,N-Carbonyldiimidazole by LC for an in-process control test. | Borges-Muñoz, A., et al. 2022. J Pharm Biomed Anal. 207: 114395. PMID: 34628292
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N,N′-Carbonyldiimidazole, 5 g | sc-208070 | 5 g | $30.00 | |||
N,N′-Carbonyldiimidazole, 10 g | sc-208070A | 10 g | $44.00 |