N-Nitrosoethylmethylamine (CAS 10595-95-6)
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N-Nitrosomethylethylamine, abbreviated as NMEA, is an organic compound belonging to the nitrosamine class. It can be used to investigate the reactivity of nitrosamines and other nitrogen-based compounds. N-Nitrosomethylethylamine is also used to study the impacts of nitrosamine exposure on human health, given its identification as a carcinogen. The mechanism of action of N-Nitrosomethylethylamine mirrors that of other nitrosamines. When N-Nitrosomethylethylamine comes into contact with the body, it can react with proteins and DNA, leading to the formation of DNA adducts. These DNA adducts can induce mutations within the DNA, potentially triggering the onset of cancer. N-Nitrosomethylethylamine can also react with proteins, leading to the formation of protein adducts, which can interfere with cellular processes.
N-Nitrosoethylmethylamine (CAS 10595-95-6) References
- Identification and quantification of seven volatile n-nitrosamines in cosmetics using gas chromatography/chemical ionization-mass spectrometry coupled with head space-solid phase microextraction. | Choi, NR., et al. 2016. Talanta. 148: 69-74. PMID: 26653425
- Determination of N-nitrosamines in cosmetic products by vortex-assisted reversed-phase dispersive liquid-liquid microextraction and liquid chromatography with mass spectrometry. | Miralles, P., et al. 2018. J Sep Sci. 41: 3143-3151. PMID: 29878646
- Metabolism of chemical carcinogens by cultured human and rat bladder epithelial cells. | Autrup, H., et al. 1981. Carcinogenesis. 2: 763-8. PMID: 6269774
- Metabolism of N-nitrosamines by cultured human and rat esophagus. | Autrup, H. and Stoner, GD. 1982. Cancer Res. 42: 1307-11. PMID: 7060009
- Volatile N-nitrosamines in gastric juice of patients with various conditions of the gastrointestinal tract determined by gas chromatography-mass spectrometry and related to intragastric pH and nitrate and nitrite levels. | Dallinga, JW., et al. 1998. Cancer Lett. 124: 119-25. PMID: 9500200
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Nitrosoethylmethylamine, 100 mg | sc-471231 | 100 mg | $322.00 |