N-Nitrosobis(2-oxopropyl)amine (CAS 60599-38-4)
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N-Nitrosobis(2-oxopropyl)amine is a nitrosamine compound that has been the subject of significant research interest in the field of chemical carcinogenesis. Chemists and toxicologists examine the metabolic pathways through which this compound is activated and detoxified in the body, which are critical for understanding its mutagenic and carcinogenic potential. The compound′s interaction with cellular DNA is particularly important, as it may lead to mutations that contribute to oncogenesis. Environmental scientists also study the presence and formation of similar nitrosamines in various contexts, including food processing and tobacco smoke, to assess exposure risks. Additionally, research involving N-Nitrosobis(2-oxopropyl)amine contributes to the development of strategies for cancer prevention, as understanding its carcinogenic activity can inform the design of inhibitors that mitigate its effects.
N-Nitrosobis(2-oxopropyl)amine (CAS 60599-38-4) References
- Expression of matrix metalloproteinase 2 (MMP-2), membrane-type 1 MMP and tissue inhibitor of metalloproteinase 2 and activation of proMMP-2 in pancreatic duct adenocarcinomas in hamsters treated with N-nitrosobis(2-oxopropyl)amine. | Iki, K., et al. 1999. Carcinogenesis. 20: 1323-9. PMID: 10383907
- The metabolism of the pancreas carcinogen N-nitrosobis(2-oxopropyl)amine by hamster pancreas duct epithelial cell clones; evidence for different metabolic efficiencies and response to cytochrome P450 inducers. | Kolar, C. and Lawson, T. 2000. JOP. 1: 13-8. PMID: 11847459
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- Modifying effects of 1,2-dichloropropane on N-nitrosobis(2-oxopropyl)amine-induced cholangiocarcinogenesis in male Syrian hamsters. | Gi, M., et al. 2015. J Toxicol Sci. 40: 647-56. PMID: 26354381
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- Effect of Fucoxanthinol on Pancreatic Ductal Adenocarcinoma Cells from an N-Nitrosobis(2-oxopropyl)amine-initiated Syrian Golden Hamster Pancreatic Carcinogenesis Model. | Terasaki, M., et al. 2021. Cancer Genomics Proteomics. 18: 407-423. PMID: 33994364
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- A potent pancreatic carcinogen in Syrian hamsters: N-nitrosobis(2-oxopropyl)amine. | Pour, P., et al. 1977. J Natl Cancer Inst. 58: 1449-53. PMID: 857032
- d-Limonene inhibits N-nitrosobis(2-oxopropyl)amine induced hamster pancreatic carcinogenesis. | Nakaizumi, A., et al. 1997. Cancer Lett. 117: 99-103. PMID: 9233838
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Nitrosobis(2-oxopropyl)amine, 100 mg | sc-212257 | 100 mg | $332.00 | |||
N-Nitrosobis(2-oxopropyl)amine, 1 g | sc-212257A | 1 g | $2336.00 |