Molecular structure of N-Nitroso(2-hydroxyethyl)glycine, CAS Number: 80556-89-4
N-Nitroso(2-hydroxyethyl)glycine (CAS 80556-89-4)
Alternate Names:
2-[(2-Hydroxyethyl)nitrosoamino]acetic Acid; N-(2-Hydroxyethyl)-N-carboxymethylnitrosamine
Application:
N-Nitroso(2-hydroxyethyl)glycine is a metabolite of N-mononitrosopiperazine (NPz) and N,N′-dinitrosopiperazine (DNPz)
CAS Number:
80556-89-4
Molecular Weight:
148.12
Molecular Formula:
C4H8N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N-Nitroso(2-hydroxyethyl)glycine, known as C-HEN, is the metabolite of N-mononitrosopiperazine (NPz) and N,N′-dinitrosopiperazine (DNPz). Extensive research has been conducted on N-Nitroso(2-hydroxyethyl)glycine due to its potential applications in cancer research. The compound has demonstrated the ability to cause DNA damage and mutations that can lead to the development of cancer. Furthermore, animal models have shown that N-Nitroso(2-hydroxyethyl)glycine is a potent carcinogen, making it useful for studying the mechanisms of carcinogenesis. N-Nitroso(2-hydroxyethyl)glycine is also known to induce oxidative stress and inflammation as well as alter gene expression and cell signaling pathways.
N-Nitroso(2-hydroxyethyl)glycine (CAS 80556-89-4) References
- Endogenous incorporation of nitric oxide from L-arginine into N-nitrosomorpholine stimulated by Escherichia coli lipopolysaccharide in the rat. | Leaf, CD., et al. 1991. Carcinogenesis. 12: 537-9. PMID: 1849054
- Comparative metabolism and urinary excretion of N-mononitrosopiperazine and N,N'-dinitrosopiperazine in the rat. | Tricker, AR., et al. 1991. Cancer Lett. 59: 165-9. PMID: 1884373
- Bacterial formation of N-nitroso compounds from administered precursors in the rat stomach after omeprazole-induced achlorhydria. | Calmels, S., et al. 1991. Carcinogenesis. 12: 435-9. PMID: 1901250
- Comparative tumorigenicity of N-nitroso-2-hydroxymorpholine, N-nitrosodiethanolamine and N-nitrosomorpholine in A/J mice and F344 rats. | Hecht, SS., et al. 1989. Carcinogenesis. 10: 1475-7. PMID: 2752522
- N-nitrosodiethanolamine is activated in the rat to an ultimate genotoxic metabolite by sulfotransferase. | Sterzel, W. and Eisenbrand, G. 1986. J Cancer Res Clin Oncol. 111: 20-4. PMID: 3456349
- Detection of mutations in bacteria and of DNA damage and amplified DNA sequences in mammalian cells as a systematic test strategy for elucidating biological activities of chemical carcinogens. | Pool, BL., et al. 1986. Food Chem Toxicol. 24: 685-91. PMID: 3536693
- Alcoholdehydrogenase as an activating enzyme for N-nitrosodiethanolamine (NDELA): in vitro activation of NDELA to a potent mutagen in Salmonella typhimurium. | Eisenbrand, G., et al. 1984. J Cancer Res Clin Oncol. 108: 76-80. PMID: 6378917
- N-Nitroso-2-hydroxymorpholine, a mutagenic metabolite of N-nitrosodiethanolamine. | Hecht, SS. 1984. Carcinogenesis. 5: 1745-7. PMID: 6499128
- A sensitive method for detecting in vivo formation of N-nitrosomorpholine and its application to rats given low doses of morpholine and sodium nitrite. | Hecht, SS. and Morrison, JB. 1984. Cancer Res. 44: 2873-7. PMID: 6722816
- N-Nitroso(2-hydroxyethyl)glycine, a urinary metabolite of N,N-dinitrosopiperazine with potential utility as a monitor for its formation in vivo from piperazine. | Hecht, SS., et al. 1984. Carcinogenesis. 5: 979-81. PMID: 6733859
- Metabolic alpha-hydroxylation of N-nitrosomorpholine and 3,3,5,5-tetradeutero-N-nitrosomorpholine in the F344 rat. | Hecht, SS. and Young, R. 1981. Cancer Res. 41: 5039-43. PMID: 7307006
- DNA damage in mononuclear blood cells of metal workers exposed to N-nitrosodiethanolamine in synthetic cutting fluids. | Fuchs, J., et al. 1995. Mutat Res. 342: 95-102. PMID: 7885399
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Nitroso(2-hydroxyethyl)glycine, 10 mg | sc-212256 | 10 mg | $374.00 |