Molecular structure of N-Nitroso-N-methylaniline, CAS Number: 614-00-6
N-Nitroso-N-methylaniline (CAS 614-00-6)
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Alternate Names:
N-Methyl-N-nitrosoaniline; N-Nitrosomethylphenylamine; Phenylmethylnitrosamine
Application:
N-Nitroso-N-methylaniline is a compounds used to study enzymatic denitrosation
CAS Number:
614-00-6
Molecular Weight:
136.15
Molecular Formula:
C7H8N2O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N-Nitroso-N-methylaniline is a nitrosylated N-methyl aniline that is described to form adducts with DNA. N-Nitroso-N-methylaniline is useful for studying enzymatic denitrosation processes. N-demethylation of N-Nitroso-N-methylaniline catalysed by cytochrome P450 is described to proceed through an electrophilic benzenediazonium ion which is demonstrated to form triazene DNA adducts at the N6-position of adenine residues.
N-Nitroso-N-methylaniline (CAS 614-00-6) References
- Direct evidence for the formation of deoxyribonucleotide adducts from carcinogenic N-nitroso-N-methylaniline revealed by the 32P-postlabeling technique. | Stiborová, M., et al. 1999. Cancer Lett. 138: 61-6. PMID: 10378774
- Role of cytochrome P-450IIE1 in N-nitroso-N-methylaniline induced hepatocyte cytotoxicity. | Quan, Z., et al. 1992. Chem Biol Interact. 83: 221-33. PMID: 1516150
- Mechanism of DNA binding by the oesophageal carcinogen N-nitroso-N-methylaniline. | Koepke, SR., et al. 1991. IARC Sci Publ. 346-50. PMID: 1855878
- Metabolic denitrosation of N-nitroso-N-methylaniline: detection of amine-metabolites. | Scheper, T., et al. 1991. Chem Biol Interact. 77: 81-96. PMID: 1983965
- The binding affinity of carcinogenic N-nitrosodimethylamine and N-nitrosomethylaniline to cytochromes P450 2B4, 2E1 and 3A6 does not dictate the rate of their enzymatic N-demethylation. | Sulc, M., et al. 2010. Gen Physiol Biophys. 29: 175-85. PMID: 20577029
- Evidence for an unstable DNA adduct from N-nitroso-N-methylaniline. | Koepke, SR., et al. 1990. Chem Res Toxicol. 3: 17-20. PMID: 2131819
- Demonstration of in vivo formation of the nitrosamine N-nitroso-N-methylaniline from amyl nitrite. | Mirvish, SS. and Ramm, MD. 1987. Cancer Lett. 36: 125-9. PMID: 2887279
- An investigation of the metabolism of N-nitroso-N-methylaniline by phenobarbital- and pyrazole-induced Sprague-Dawley rat liver and esophagus derived S-9. | Gold, B., et al. 1987. Chem Biol Interact. 61: 215-28. PMID: 3568192
- N-nitroso-N-methylaniline: possible mode of DNA modification. | Koepke, SR., et al. 1987. IARC Sci Publ. 68-70. PMID: 3679445
- [The effect of N-nitroso-N-methylaniline and N-nitroso-N-ethylaniline on the rat embryo]. | Aleksandrov, VA. 1968. Vopr Onkol. 14: 37-8. PMID: 5653598
- The effect of substituents in the aromatic ring on carcinogenicity of N-nitrosomethylaniline in F344 rats. | Kroeger-Koepke, MB., et al. 1983. Carcinogenesis. 4: 157-60. PMID: 6402317
- Metabolism of 15N-labelled N-nitrosodimethylamine and N-nitroso-N-methylaniline by isolated rat hepatocytes. | Koepke, SR., et al. 1984. Biochem Pharmacol. 33: 1509-13. PMID: 6732867
- alpha-Hydroxylation pathway in the in vitro metabolism of carcinogenic nitrosamines: N-nitrosodimethylamine and N-nitroso-N-methylaniline. | Kroeger-Koepke, MB., et al. 1981. Proc Natl Acad Sci U S A. 78: 6489-93. PMID: 6947239
- Metabolism of carcinogenic N-nitroso-N-methylaniline by purified cytochromes P450 2B1 and P450 2B2. | Stiborová, M., et al. 1996. Cancer Lett. 110: 11-7. PMID: 9018075
- An investigation of the metabolism of N-nitrosodimethylamine and N-nitrosomethylaniline by horseradish peroxidase in vitro. | Stiborová, M., et al. 1997. Gen Physiol Biophys. 16: 285-97. PMID: 9452949
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Nitroso-N-methylaniline, 25 mg | sc-208051A | 25 mg | $179.00 | |||
N-Nitroso-N-methylaniline, 50 mg | sc-208051 | 50 mg | $272.00 | |||
N-Nitroso-N-methylaniline, 100 mg | sc-208051B | 100 mg | $404.00 | |||
N-Nitroso-N-methylaniline, 250 mg | sc-208051C | 250 mg | $914.00 | |||
N-Nitroso-N-methylaniline, 500 mg | sc-208051D | 500 mg | $1638.00 |